Senti Bio Highlights Initial Gene Circuit Data From Collaborations at the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting
Five presentations showcase the modularity and applicability of Senti’s Gene Circuit technology in NK cells, T cells, AAVs, iPSCs, and macrophages
SOUTH SAN FRANCISCO, Calif., May 20, 2023 (GLOBE NEWSWIRE) -- Senti Biosciences, Inc. (Nasdaq: SNTI) (“Senti Bio”), a biotechnology company innovating next-generation cell and gene therapies using its proprietary Gene Circuit platform, today announced multiple presentations highlighting the broad application of its Gene Circuit technologies in multiple modalities at the American Society of Gene and Cell Therapy (ASGCT) annual meeting in Los Angeles, CA.
“Our Gene Circuits are poised to potentially disrupt high-priority, unmet need diseases with smarter cell and gene therapies that can confer better activity, precision, and control,” said Timothy Lu, M.D., Ph.D., Chief Executive Officer and Co-Founder of Senti Bio. “Having such a strong presence at ASGCT validates the utility of our technology across multiple modalities, including NK cells, T cells, AAVs, iPSCs, and macrophages. We thank our partners for the productive collaborations and look forward to continued application of our platform to other disease indications.”
The presentations and posters can be accessed on the Scientific Presentations & Publications section of the Senti Bio website.
Engineering pharmacologically relevant, FDA-approved small-molecule-regulated gene circuits for therapeutic applications in the brain
Showcases gene circuit application in iPSC-derived cells in collaboration with BlueRock Therapeutics
Massively parallel and systematic engineering platform for highly compact, cell-type specific, and potent Smart Sensor promoters for precision retinal gene therapies
Showcases gene circuit application in AAV gene therapy in collaboration with Spark Therapeutics
Senti Bio’s Poster Presentations
High-throughput engineering of Logic Gated-gene circuits for precision CAR cell therapies
- Senti Bio has developed a robust platform for automated high throughput screening (HTS) of hundreds of CARs in parallel, in one self-contained, concurrent, end-to-end process.
- Automated HTS enables the programming of Logic Gated CAR cells to achieve high protection of healthy cells using the NOT GATE technology without compromising tumor-killing function.
- The data validates the Company’s NOT GATE technology in T cells as well as NK cells, thus enabling the ability to expand the Logic Gate technology into a wide range of cancers.
Designing cell-state-specific synthetic promoters as Smart Sensors to control macrophage polarization
In collaboration with BlueRock Therapeutics
- Senti Bio discovered and validated M1-state-specific macrophage promoters that can be rationally re-engineered to improve promoter strength and M1 state-specific activity.
- State-specific synthetic promoter libraries were bioinformatically designed for high-throughput Massively Parallel Reporter Assay (MPRA) screening. The data shows that hits from these promoter libraries can be stronger and more selective than native promoters.
- The data demonstrated that state-specific promoters can be built into Smart Sensor circuits to control macrophage polarization logic.
BlueRock Therapeutics’ Poster Presentation
Engineering a gene circuit-enabled cell therapy with a Tamoxifen regulated safety switch for inducible cell death in human pluripotent stem cells (hPSCs) and their derivatives
BlueRock Therapeutics poster utilizing Senti Bio’s Gene Circuit technology
- One potential safeguard against risks associated with hPSCs is the implementation of a safety switch that can ablate transplanted cells from a patient.
- Senti Bio’s Safety Switch gene circuit has been successfully engineered into BlueRock's hPSCs for robust, stable, and ubiquitous expression of biological cargo.
- BlueRock has demonstrated that hPSCs harboring a novel TamCasp9-engineered Safety Switch gene circuit, expressed robustly from the GAPDH locus, enables transplanted cells to be removed with pharmacologically relevant concentrations of tamoxifen metabolites.
About Senti Bio
Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases using novel and unprecedented approaches. To accomplish this, we are building a synthetic biology platform that may enable us to program next-generation cell and gene therapies with what we refer to as Gene Circuits. These novel and proprietary Gene Circuits are designed to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We aim to design Gene Circuits to improve the intelligence of cell and gene therapies in order to enhance their therapeutic effectiveness, precision, and durability against a broad range of diseases that conventional medicines do not readily address.
Our synthetic biology platform utilizes off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cells, outfitted with Gene Circuit technologies, to target particularly challenging liquid and solid tumor oncology indications. Our lead product candidate is SENTI-202 for the treatment of CD33 and/or FLT3 expressing hematologic malignancies, such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Additionally, our SENTI-401 program is being designed for the treatment of colorectal cancer (CRC) and other CEA-positive cancers. We have also demonstrated in preclinical studies the potential breadth of our Gene Circuits in other modalities, including T cells, adeno-associated viruses (AAVs) and induced pluripotent stem cells (iPSCs), and diseases outside of oncology; and we have executed partnerships with Spark Therapeutics and BlueRock Therapeutics to advance these capabilities.
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