0001854270-24-000116 | 10-Q | XBRL Viewer

CIRM Grant	9 Months Ended
CIRM Grant	Sep. 30, 2024
Government Assistance [Abstract]
CIRM Grant	CIRM Grant On August 3, 2024, the Company executed an agreement with CIRM for a total grant award of $8.0 million in support of the research project related to the ongoing clinical development of SENTI-202. The award is payable to the Company upon achievement of milestones that are primarily based on patient enrollment in the Company’s SENTI-202 clinical trial. Under the terms of the CIRM Grant, the Company has certain obligations of co-funding up to $4.8 million and is required to provide CIRM timely progress and financial update reports. Under the terms of the CIRM Grant, the Company is obligated to pay royalties and licensing fees based on 0.1% of net commercial revenue of CIRM-funded product candidates or CIRM-funded technology for every $1.0 million of CIRM funding received. This payment continues for either 10 years from the first commercial sale of the drug product or until the total royalties paid equal nine times the original CIRM Grant. As an alternative to revenue sharing, the Company has the option to convert the CIRM Grant to a loan. In the event the Company exercises its right to convert the CIRM Grant to a loan, the Company would be obligated to repay the loan within 10 business days of making such election. Repayment amounts vary dependent upon the phase of clinical development of SENTI-202 at the time of the Company’s election, ranging from 80% to 100% plus interest at 10% plus the 90-day Secured Overnight Financing Rate (“SOFR”). As of September 30, 2024, the Company has received an aggregate of $2.4 million which was recorded as other liabilities, net of current portion in the condensed consolidated balance sheets.

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Sep. 30, 2024
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Revenue - Contract Revenue (Details) - USD ($)	1 Months Ended	3 Months Ended		9 Months Ended
Revenue - Contract Revenue (Details) - USD ($)	Apr. 30, 2021	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Nov. 30, 2023
Disaggregation of Revenue [Line Items]
Total revenue		$ 0	$ 338,000	$ 0	$ 2,561,000
Revenue recognized during period previously included in deferred revenue			$ 200,000		$ 800,000
Spark
Disaggregation of Revenue [Line Items]
Agreement evaluation period	24 months
Spark \| Minimum
Disaggregation of Revenue [Line Items]
Agreement termination advance notice period	90 days
Spark \| Maximum
Disaggregation of Revenue [Line Items]
Agreement termination advance notice period	180 days
Spark \| License
Disaggregation of Revenue [Line Items]
Variable consideration	$ 3,000,000.0
Spark \| License \| Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-05-01
Disaggregation of Revenue [Line Items]
Expected timing of satisfaction	2 years
Celest Therapeutics (Shanghai) Co. Ltd.
Disaggregation of Revenue [Line Items]
Variable consideration						$ 156,000,000

Net Loss Per Share - Schedule of Basic and Diluted Net Earnings (loss) Per Common Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Sep. 30, 2024	Sep. 30, 2023
Earnings Per Share [Abstract]
Net loss from continuing operations	$ (28,866)			$ (36,615)			$ (52,180)	$ (64,718)
Net income from discontinued operations	0			21,692			0	12,376
Net loss	$ (28,866)	$ (11,203)	$ (12,111)	$ (14,923)	$ (18,697)	$ (18,722)	$ (52,180)	$ (52,342)
Weighted-average shares used in computing net loss per share, basic (in shares)	4,577,122			4,447,223			4,573,307	4,427,458
Weighted-average shares used in computing net loss per share, diluted (in shares)	4,577,122			4,447,223			4,573,307	4,427,458
Net loss per share from continuing operations, basic (in dollars per share)	$ (6.31)			$ (8.24)			$ (11.41)	$ (14.62)
Net loss per share from continuing operations, diluted (in dollars per share)	(6.31)			(8.24)			(11.41)	(14.62)
Net income per share from discontinued operations, basic (in dollars per share)	0			4.88			0	2.80
Net income per share from discontinued operations, diluted (in dollars per share)	0			4.88			0	2.80
Earnings Per Share
Net loss per share attributable to common stockholders, diluted (in shares)	(6.31)			(3.36)			(11.41)	(11.82)
Net loss per share attributable to common stockholders, basic (in shares)	$ (6.31)			$ (3.36)			$ (11.41)	$ (11.82)

Condensed Consolidated Statements of Stockholders’ Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2022		4,406,137
Beginning balance at Dec. 31, 2022	$ 127,263	$ 0	$ 300,548	$ 1	$ (173,286)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	34		34
Stock-based compensation expense	3,763		3,763
Unrealized gain (loss) on investments	2			2
Net loss	(18,722)				(18,722)
Ending balance (in shares) at Mar. 31, 2023		4,407,403
Ending balance at Mar. 31, 2023	112,340	$ 0	304,345	3	(192,008)
Beginning balance (in shares) at Dec. 31, 2022		4,406,137
Beginning balance at Dec. 31, 2022	127,263	$ 0	300,548	1	(173,286)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Unrealized gain (loss) on investments	(1)
Net loss	(52,342)
Ending balance (in shares) at Sep. 30, 2023		4,447,650
Ending balance at Sep. 30, 2023	82,936	$ 0	308,564	0	(225,628)
Beginning balance (in shares) at Mar. 31, 2023		4,407,403
Beginning balance at Mar. 31, 2023	112,340	$ 0	304,345	3	(192,008)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	34		34
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)		37,715
Issuance of common stock under Employee Stock Purchase Plan (ESPP)	308		308
Stock-based compensation expense	3,434		3,434
Unrealized gain (loss) on investments	(3)			(3)
Net loss	(18,697)				(18,697)
Ending balance (in shares) at Jun. 30, 2023		4,446,384
Ending balance at Jun. 30, 2023	97,416	$ 0	308,121	0	(210,705)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	34		34
Stock-based compensation expense	409		409
Unrealized gain (loss) on investments	0
Net loss	(14,923)				(14,923)
Ending balance (in shares) at Sep. 30, 2023		4,447,650
Ending balance at Sep. 30, 2023	$ 82,936	$ 0	308,564	0	(225,628)
Beginning balance (in shares) at Dec. 31, 2023	4,569,900	4,569,900
Beginning balance at Dec. 31, 2023	$ 66,913	$ 1	311,256	0	(244,344)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	34		34
Stock-based compensation expense	1,258		1,258
Net loss	(12,111)				(12,111)
Ending balance (in shares) at Mar. 31, 2024		4,571,166
Ending balance at Mar. 31, 2024	$ 56,094	$ 1	312,548	0	(256,455)
Beginning balance (in shares) at Dec. 31, 2023	4,569,900	4,569,900
Beginning balance at Dec. 31, 2023	$ 66,913	$ 1	311,256	0	(244,344)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Unrealized gain (loss) on investments	0
Net loss	$ (52,180)
Ending balance (in shares) at Sep. 30, 2024	4,586,957	4,586,957
Ending balance at Sep. 30, 2024	$ 15,994	$ 1	312,517	0	(296,524)
Beginning balance (in shares) at Mar. 31, 2024		4,571,166
Beginning balance at Mar. 31, 2024	56,094	$ 1	312,548	0	(256,455)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	33		33
Stock-based compensation expense	(776)		(776)
Net loss	(11,203)				(11,203)
Ending balance (in shares) at Jun. 30, 2024		4,572,432
Ending balance at Jun. 30, 2024	44,148	$ 1	311,805	0	(267,658)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of early exercise of common stock options (in shares)		1,266
Vesting of early exercise of common stock options	34		34
Common Stock Purchase Agreement settled in common stock, net of fees (in shares)		3,593
Common Stock Purchase Agreement settled in common stock, net of fees	10		10
Issuance of common stock for vesting of restricted stock units (in shares)		9,666
Stock-based compensation expense	668		668
Unrealized gain (loss) on investments	0
Net loss	$ (28,866)				(28,866)
Ending balance (in shares) at Sep. 30, 2024	4,586,957	4,586,957
Ending balance at Sep. 30, 2024	$ 15,994	$ 1	$ 312,517	$ 0	$ (296,524)

Related Parties

9 Months Ended

Sep. 30, 2024

Related Parties

GeneFab Transaction

On August 7, 2023, the Company entered into a framework agreement (the “GeneFab Framework Agreement”) with GeneFab and Valere Bio, Inc., a Delaware corporation and the parent company of GeneFab, which is wholly owned by Celadon Partners, LLC, pursuant to which the Company, subject to the terms and conditions therein, sold, assigned and transferred its rights, title and interest in certain of the assets and contractual rights, including all of the Company’s equipment at the Company’s facilities in Alameda and certain of the Company’s non-oncology license rights, intellectual property related to the schematics for and design of the Alameda facility, and subleased to GeneFab its premises under a lease agreement for the Alameda facility. The transaction provided the Company with additional capital in the form of a note receivable and rights to future manufacturing and research activities performed by GeneFab at market rates and reduced longer term operating expenses.

Concurrently with the transaction, the Company and GeneFab entered into a development and manufacturing services agreement (the “GeneFab Services Agreement”), pursuant to which GeneFab will provide certain services to the Company using the subleased Alameda facility and acquired equipment. As part of this transaction, the Company entered into a transition services agreement with GeneFab whereby certain services are to be provided by each party to the other party during a transition period beginning on the closing of the transaction.

The total consideration in connection with the transaction was $37.8 million, of which $18.9 million was due at closing and was netted against prepayment due to GeneFab for future manufacturing and research activities. The remaining $18.9 million consideration (the “GeneFab Note Receivable”) is subject to satisfaction of certain conditions. The Company elected to account for the GeneFab Note Receivable under the fair value option and recorded the GeneFab Note Receivable at its fair value of $16.6 million at the closing date of the transaction. The GeneFab Note Receivable is remeasured each reporting period with changes from remeasurement included in other income (expense) in the condensed consolidated statements of operations and comprehensive loss. Refer to Note 4. Fair Value Measurements.

The Company was entitled to $18.9 million in future manufacturing and research activities to be rendered by GeneFab under the services agreement, which are recorded in GeneFab prepaid expenses on the condensed consolidated balance sheet. The Company determined that the $18.9 million for future manufacturing and research activities, inclusive of the volume discount provided, was executed at market terms and does not result in any impact to the total consideration received from GeneFab for the disposal of the business. As of September 30, 2024, $3.9 million of this initial prepaid amount is remaining for future manufacturing and research activities.

As part of the transaction, the Company subleased the facility in Alameda, California to GeneFab which will support the clinical manufacturing of the Company’s chimeric antigen receptor natural killer (CAR-NK) programs, including SENTI-202. As a result of sublease event, the Company recognized an impairment of long-lived assets of $25.7 million for the nine months ended September 30, 2023 due to the impairment of the Company’s leasehold improvements. Refer to Note 6. Operating Leases, for additional information on the sublease.

The Company agreed to grant a license to GeneFab under certain of its intellectual property rights to conduct manufacturing services and to research, develop, manufacture and commercialize products outside of oncology, pursuant to a license agreement (the “Non-Oncology License”).

In connection with the transaction, Philip Lee, Ph.D., former Co-Founder and Chief Technology Officer of the Company, assumed the role of Chief Executive Officer of GeneFab. Additionally, GeneFab extended offers of employment to 45 of the Company's employees formerly employed in its research and development and manufacturing functions. All 45 employees accepted the offers of employment and are actively engaged in providing manufacturing and research activities to the Company.

GeneFab was granted an option to purchase up to 1,963,344 shares (i.e., up to $20.0 million worth) of the Company’s common stock at a per share purchase price of $10.18670 (the “GeneFab Option”). The GeneFab Option becomes exercisable upon the execution of the license agreement, no later than August 7, 2026. The GeneFab Option may be exercised in installments of common stock equal to no more than 19.9% of the Company’s outstanding shares of common stock as of the closing date of the transaction. The purchase of the remaining shares under the GeneFab Option requires approval by the Company’s stockholders. The Company determined that the GeneFab Option was a derivative as the terms of the instrument contain certain provisions that preclude equity classification in accordance with ASC 815. As such, the GeneFab Option was recorded as a liability at its fair value of $9.6 million at the closing date of the transaction and subsequently remeasured with changes in fair value recorded in other income (expense) in the condensed consolidated statements of operations and comprehensive loss. Refer to Note 4. Fair Value Measurements.

As additional consideration for the transaction, the Company and GeneFab entered into a seller economic share agreement (the “GeneFab Economic Share”), pursuant to which the Company will be entitled to receive ten percent of the realized gains of GeneFab’s parent company arising and resulting from any cash or in-kind distributions from GeneFab in connection with a dividend or sale event, subject to the terms and conditions of the GeneFab Economic Share. The Company elected to account for the GeneFab Economic Share under the fair value option and recorded the GeneFab Economic Share at its fair value of $1.8 million at the date of the transaction. The GeneFab Economic Share is remeasured each reporting period with changes from remeasurement included in other income (expense) in

the condensed consolidated statements of operations and comprehensive loss. Refer to Note 4. Fair Value Measurements.

The Company determined that GeneFab is a variable interest entity (“VIE”) since its total equity at risk is not sufficient to finance its activities without additional subordinated financial support. The Company performed a qualitative analysis to determine if it is the primary beneficiary of GeneFab and determined it does not have the power to direct the significant activities of GeneFab. As a result, the Company determined it is not the primary beneficiary and therefore does not consolidate GeneFab.

Refer to Note 14. Related Parties, for GeneFab related party considerations.

Gain on the Disposal of Business

As the assets and contractual rights transferred to GeneFab were determined to constitute a business as defined in ASC 805, Business Combinations, the Company accounted for the disposal by applying the derecognition guidance in ASC 810, Consolidation, which requires that a gain or loss be recognized for the difference between the carrying value of the assets sold and the fair value of the consideration received (or receivable).

As of August 7, 2023, the total fair value of the consideration was determined to be $37.3 million, including the GeneFab prepaid expenses of $18.9 million, the estimated fair value of the GeneFab Note Receivable of $16.6 million and the estimated fair value of the GeneFab Economic Share of $1.8 million. Out of the total consideration, $9.6 million was allocated to the GeneFab Option, representing its estimated fair value as of the closing date.

In connection with the sale, the Company recognized a gain on disposal in the amount of $21.9 million in net income from discontinued operations during the year ended December 31, 2023, representing the excess of the fair value of the consideration (net of the portion allocated to the GeneFab Option) over the carrying value of the assets sold of $5.5 million. The gain on disposal was primarily related to the transfer of the non-oncology intellectual property to GeneFab which had no carrying value.

Discontinued Operations

In accordance with ASC 205, Presentation of Financial Statements (“ASC 205”), the Company determined that the sale of the non-oncology business, including the equipment and transfer of in-house manufacturing activities in the Alameda facility, to GeneFab represented a strategic shift that will have a major effect on the Company’s operations and financial results, thus meeting the criteria to be reported as discontinued operations. Discontinued operations include the cost and depreciation of equipment and related deposits or liabilities, manufacturing personnel-related costs including costs arising as a result of the disposal such as equity award modifications and severance, and the gain from the disposal of the business.

As of September 30, 2024 and December 31, 2023, there were no assets related to the discontinued operations, and the liabilities related to the discontinued operations were zero and $0.2 million, respectively.

There were no material operating expenses related to the discontinued operations since August 2023, when the transaction with GeneFab closed.

The following table summarizes the condensed operating results of the discontinued operations for the three and nine months ended September 30, 2023 (in thousands):


	Three Months Ended September 30,		Nine months ended September 30,
	2023		2023
Operating expenses:
Research and development	$	1,641	$	9,975
General and administrative	(1,478)		(496)
Total operating expenses	163		9,479
Loss from discontinued operations	(163)		(9,479)
Other expense	(6)		(6)
Gain on disposal of business	21,861		21,861
Net income from discontinued operations	$	21,692	$	12,376

The following table summarizes the condensed cash flow information of the discontinued operations for the nine months ended September 30, 2023 (in thousands):


	Nine months ended September 30,
	2023
Operating activities (noncash adjustments to net income):
Depreciation	$	185
Stock-based compensation	(2,022)

Investing activities:
Purchases of property and equipment	$	(4,079)

Related Parties

Bayer Healthcare LLC

On May 21, 2021, the Company entered into a collaboration and option agreement (“BlueRock Agreement”) with BlueRock, a wholly-owned subsidiary of Bayer, pursuant to which the Company granted to BlueRock an option (“BlueRock Option”), on a collaboration program-by-collaboration program basis, to obtain an exclusive or non-exclusive license to develop, manufacture and commercialize cell therapy products that contain cells of specified types and which incorporate an option gene circuit from such collaboration program or a closely related derivative gene circuit. The Company was responsible for up to $10 million in costs and expenses incurred in connection with the research plan and related activities to be conducted over a three-year research term as specified in the collaboration and option agreement. The Company completed the initial research plan and related activities in May 2024. If the Company and BlueRock agree to add new research activities to the research plan, then BlueRock will be obligated to reimburse the Company for the costs and expenses incurred.

The Company concluded that the BlueRock Agreement is not within the scope of ASC 808, Collaborative Arrangements, because the Company did not receive any consideration and therefore, is not exposed to both significant risks and rewards for the arrangement. The Company also determined that the agreement is also not currently within the scope of ASC 606 because the BlueRock Agreement does not currently meet the criteria of a contract with a customer, and will not be within the scope of ASC 606 until any consideration is paid. Potential future milestone payments and royalties are subject to BlueRock’s exercise of the BlueRock Option and execution of a commercial license agreement by both parties. Under the BlueRock Agreement, the specific financial terms for milestone payments and royalties will be negotiated and agreed to only after the option is exercised. As of September 30, 2024, Bayer has not exercised its option for a license.

Bayer held 13% of the outstanding shares of the Company’s common stock as of September 30, 2024 and December 31, 2023. Accordingly, Bayer is considered a related party.

Seer, Inc.

In January 2023, the Company acquired lab automation equipment purchased from Seer, Inc. (“Seer”) (NASDAQ: SEER). Omid Farokhzad, a member of the Company’s board of directors is the Chief Executive Officer of Seer. The consideration of $0.2 million, plus interest, will be paid over a two-year period, and title will transfer to the Company upon final payment. The transaction was classified as a finance lease in accordance with ASC 842.

GeneFab, LLC.

As a result of the transaction with GeneFab (refer to Note 3. GeneFab Transaction), whereby Philip Lee, Ph.D., the former Co-Founder and Chief Technology Officer of the Company, assumed the role of Chief Executive Officer of GeneFab, GeneFab is a related party. In connection with the disposal of the business, the Company received the GeneFab Note Receivable and the GeneFab Economic Share and provided GeneFab with the GeneFab Option. Refer to Note 4. Fair Value Measurements.

On June 12, 2024, the Company entered into a sublease agreement with GeneFab for a portion of the Company’s corporate headquarters in South San Francisco. The Company has also subleased its manufacturing facility in Alameda to GeneFab and recorded total sublease income of $4.7 million including variable costs charged for the nine months ended September 30, 2024.

In connection with the services agreement entered into with GeneFab on August 7, 2023, the Company was entitled to $18.9 million for future services under the agreement, of which $3.9 million remained in GeneFab prepaid expenses - related party as of September 30, 2024. Additionally, amounts due from GeneFab related to costs incurred by Senti on its behalf were $0.9 million as of September 30, 2024 and were recorded in GeneFab receivable - related party on the condensed consolidated balance sheets. The Company incurred $3.8 million and $11.1 million

of research and development expenses under the services agreement during the three and nine months ended September 30, 2024.

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480990/946-20-50-2

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
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-Paragraph 5
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480990/946-20-50-5

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1
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-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.6-07(2)(g)(3))
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-URI https://asc.fasb.org/1943274/2147479134/946-220-S99-1

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1
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-URI https://asc.fasb.org/1943274/2147479134/946-220-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
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-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.6-07(2)(e))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479134/946-220-S99-1

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
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-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-6

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (a)
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-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483326/850-10-50-1

+ Details

Revenue - Grant Income (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
Revenue - Grant Income (Details) - USD ($) $ in Thousands	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Dec. 31, 2021
Disaggregation of Revenue [Line Items]
Grant income	$ 0	$ 83	$ 0	$ 583
Grant \| Small Business Innovation Research (“SBIR”)
Disaggregation of Revenue [Line Items]
Grant award					$ 2,000
Grant transaction duration (in years)					2 years
Grant income		$ 100		$ 600

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References + Details

Summary of Significant Accounting Policies (Details) $ in Millions		9 Months Ended
	Jul. 17, 2024	Sep. 30, 2024 USD ($) businessActivitiy reportableSegment	Aug. 03, 2024 USD ($)
Significant Accounting Policies [Line Items]
Number of business activities \| businessActivitiy		1
Number of reportable segments \| reportableSegment		1
Stock split ratio, common stock	0.10
GeneFab
Significant Accounting Policies [Line Items]
Prepaid expenses		$ 3.9
Accounts receivable		$ 1.1
California Institute of Regenerative Medicine (“CIRM”) \| Grant
Significant Accounting Policies [Line Items]
Grant award			$ 8.0

Subsequent Events (Details) - California Institute of Regenerative Medicine (“CIRM”) - Grant - USD ($) $ in Millions	Nov. 01, 2024	Aug. 03, 2024
Subsequent Event [Line Items]
Grant award		$ 8.0
Subsequent Event
Subsequent Event [Line Items]
Grant award	$ 2.5

Income Tax	9 Months Ended
Income Tax	Sep. 30, 2024
Income Tax Disclosure [Abstract]
Income Tax	Income Tax The Company’s income tax provision for the three and nine months ended September 30, 2024 and 2023 is zero, respectively. While the Company is subject to federal and state income taxes in various jurisdictions, due to cumulative losses their current income tax liability is zero and deferred tax assets generated from the Company’s net operating losses have been subject to a full valuation allowance, as the Company believes it is not more likely than not that the benefit will be realized due to the Company’s losses generated to date.

- Definition

The entire disclosure for income tax.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482603/740-30-50-2

+ Details

Fair Value Measurements - Schedule of Significant Assumptions (Details) - GeneFab - Fair Value, Inputs, Level 3 $ in Thousands	Dec. 31, 2023 USD ($) $ / shares
GeneFab equity value
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Contingent consideration receivable, measurement input \| $	35,448
Expected volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Contingent consideration receivable, measurement input	0.658
Risk-free interest rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Contingent consideration receivable, measurement input	0.0393
Expected term (years)
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Contingent consideration receivable, measurement input	4.0
Equity Option \| Current stock price
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Derivative liability, measurement input \| $ / shares	6.60
Equity Option \| Expected volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Derivative liability, measurement input	0.981
Equity Option \| Risk-free interest rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Derivative liability, measurement input	0.0412
Equity Option \| Expected term (years)
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Derivative liability, measurement input	2.5

Stockholders’ Equity

9 Months Ended

Sep. 30, 2024

Equity [Abstract]

Stockholders’ Equity

Common Stock

As of September 30, 2024 and December 31, 2023, the Company’s certificate of incorporation authorized the Company to issue 500,000,000 shares of common stock at a par value of $0.0001 per share. Each share of common stock is entitled to one vote. The holders of common stock are also entitled to receive dividends whenever funds are legally available and when declared by the Company’s board of directors. As of September 30, 2024 and December 31, 2023, no dividends have been declared.

On July 10, 2024, the Board approved a reverse stock split of the Common Stock at a ratio of 1-for-10, $0.0001 par value. Effective as of 5:00 p.m. Eastern Time on July 17, 2024, the Company filed the Reverse Stock Split Amendment and effected a 1-for-10 reverse stock split of its shares of Common Stock (the “Reverse Stock Split”). All common stock amounts and references have been retroactively adjusted for all figures presented to reflect this split unless specifically stated otherwise. No fractional shares were issued in connection with the Reverse Stock Split. Stockholders who would have otherwise been entitled to receive fractional shares as a result of the Reverse Stock Split were entitled to a cash payment in lieu thereof at a price equal to the fraction to which the stockholder would have otherwise been entitled multiplied by the closing sales price per share of the Common Stock (as adjusted for the Reverse Stock Split) on the Nasdaq Capital Market on July 17, 2024, the last trading day immediately preceding the effective time of the Reverse Stock Split. Trading of the Company’s Common Stock on the Nasdaq Capital Market commenced on a split-adjusted basis as of market open on July 18, 2024, under the existing trading symbol “SNTI.”

At September 30, 2024 and December 31, 2023, the Company has reserved shares of its Common Stock for future issuance as follows:


	September 30,	December 31,
	2024	2023

Common Stock Purchase Agreement	729,111	732,704
Common stock options issued and outstanding	921,334	1,158,294
Restricted Stock Units (RSUs) issued and outstanding	56,423	22,528
Performance Stock Units (PSUs) issued and outstanding	106,806	—
Common stock shares available for future issuance under equity plans	682,695	367,228
Common stock shares available for future issuance under the 2022 Employee Stock Purchase Plan (the "ESPP")	79,387	33,632
Contingent earnout common stock	100,000	200,000
GeneFab Option	1,963,344	1,963,344
Unvested early exercised common stock	1,688	5,486
Total	4,640,788	4,483,216

Preferred Stock

In connection with the close of the Merger, the Company’s Amended and Restated Certificate of Incorporation provides the Company’s board of directors with the authority to issue $0.0001 par value preferred stock in one or more series and to establish from time to time the number of shares to be included in each such series, by adopting a resolution and filing a certification of designations. Voting powers, designations, powers, preferences and relative, participating, optional, special and other rights shall be stated and expressed in such resolutions. There were 10,000,000 shares designated as preferred stock and none were outstanding as of September 30, 2024 and December 31, 2023.

Common Stock Purchase Agreement

On August 31, 2022, the Company entered into a Common Stock Purchase Agreement and a Registration Rights Agreement, as amended and restated on July 16, 2024 (collectively referred to as the “Purchase Agreement”) with Chardan Capital Markets LLC (“Chardan”). Pursuant to the Purchase Agreement, the Company has the right, in

its sole discretion, to sell to Chardan up to the lesser of (i) $50.0 million of newly issued shares of the Company’s common stock, and (ii) the Exchange Cap (as defined below) (subject to certain conditions and limitations), from time to time during the 36-month term of the Purchase Agreement. Under the applicable NASDAQ rules, the Company may not issue to Chardan under the Purchase Agreement more than 872,704 shares of common stock, which number of shares is equal to 19.99% of the common shares outstanding immediately prior to the execution of the Purchase Agreement unless certain exceptions are met (the “Exchange Cap”). The purchase price of the shares of common stock will be determined by reference to the Volume Weighted Average Price (“VWAP”) of the common stock during the applicable purchase date, less a fixed 3% discount to such VWAP. However, the total shares to be purchased on any day may not exceed 20% of the trading volume, and the total purchase price on any day may not exceed $3.0 million. As consideration for Chardan’s commitment to purchase shares of common stock at the Company’s direction upon the terms and subject to the conditions set forth in the Purchase Agreement, upon execution of the Purchase Agreement, the Company issued 10,000 shares of its common stock to Chardan and paid a $0.4 million document preparation fee. On July 16, 2024, the Company amended and restated this Purchase Agreement (hereinafter, the “A&R Purchase Agreement”) with Chardan to update the volume weighted average price purchase mechanics of the equity facility to permit Intraday VWAP Purchases (as defined in the A&R Purchase Agreement).

The Company has issued 143,593 shares of common stock to Chardan under the A&R Purchase Agreement, including 10,000 shares issued to Chardan as consideration for its execution and delivery of the A&R Purchase Agreement, with aggregate net proceeds of $1.2 million. There were no shares issued under the Purchase Agreement during the three and nine months ended September 30, 2023. The shares issued during the three and nine months ended September 30, 2024 were 3,593.

Contingent Earnout Equity

Following the closing of the Merger, former holders of Legacy Senti common stock and preferred stock may receive up to 200,000 additional shares of the Company’s common stock in the aggregate, in two equal tranches of 100,000 shares of common stock per tranche. The first and second tranches are issuable if the closing volume weighted average price (“VWAP”) per share of common stock quoted on the Nasdaq (or the exchange on which the shares of common stock are then listed) is greater or equal to $150.00 and $200.00, respectively over any twenty trading days within any thirty-day trading period. The first tranche term is two years from the closing of the Merger (the “First Tranche Term”) and the second tranche term is three years from the closing of the Merger (the “Second Tranche Term”) and together with the First Tranche Term, the “Tranche Terms”). If there is a change of control within the applicable Tranche Term-following the closing of the Merger that results in a per share price equal to or in excess of the $150.00 and $200.00 share price milestones not previously met, then Company shall issue the earnout shares to the holders of Legacy Senti common stock and preferred stock. The $150.00 share price milestone for the first tranche was not satisfied during the First Tranche Term and any such rights to receive the first tranche of additional shares of the Company’s common stock have been cancelled and extinguished.

Contingent earnout is accounted at fair value and classified as a liability in the Company’s condensed consolidated financial statements. The Company recognized zero and $0.2 million gain for the change in fair value of contingent earnout liability for the three and nine months ended September 30, 2023, respectively. Contingent earnout liability was less than $0.1 million at September 30, 2024 and December 31, 2023.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
-Paragraph 13
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
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-URI https://asc.fasb.org/505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (i)
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

+ Details

CIRM Grant (Details) - USD ($) $ in Thousands	Aug. 03, 2024	Sep. 30, 2024	Dec. 31, 2023
Government Assistance [Line Items]
Other liabilities, net of current portion		$ 2,543	$ 0
California Institute of Regenerative Medicine (“CIRM”) \| Grant
Government Assistance [Line Items]
Grant award	$ 8,000
Co-funding obligation	$ 4,800
Royalty and licensing expense, percentage of revenue	0.10%
Royalty and licensing expense, per funding received	$ 1,000
Grant transaction duration (in years)	10 years
Royalty payment threshold, grant amount multipilier	9
Loan conversion option, threshold days for repayment (in days)	10 days
Repayment of loan, interest rate (in percent)	10.00%
Other liabilities, net of current portion		$ 2,400
California Institute of Regenerative Medicine (“CIRM”) \| Grant \| Minimum
Government Assistance [Line Items]
Repayment of loan (in percent)	80.00%
California Institute of Regenerative Medicine (“CIRM”) \| Grant \| Maximum
Government Assistance [Line Items]
Repayment of loan (in percent)	100.00%

Stockholders’ Equity (Tables)

9 Months Ended

Sep. 30, 2024

Equity [Abstract]

Schedule Of Shares Reserved For Future Issuance

At September 30, 2024 and December 31, 2023, the Company has reserved shares of its Common Stock for future issuance as follows:


	September 30,	December 31,
	2024	2023

Common Stock Purchase Agreement	729,111	732,704
Common stock options issued and outstanding	921,334	1,158,294
Restricted Stock Units (RSUs) issued and outstanding	56,423	22,528
Performance Stock Units (PSUs) issued and outstanding	106,806	—
Common stock shares available for future issuance under equity plans	682,695	367,228
Common stock shares available for future issuance under the 2022 Employee Stock Purchase Plan (the "ESPP")	79,387	33,632
Contingent earnout common stock	100,000	200,000
GeneFab Option	1,963,344	1,963,344
Unvested early exercised common stock	1,688	5,486
Total	4,640,788	4,483,216

Fair Value Measurements (Tables)

9 Months Ended

Sep. 30, 2024

Fair Value Disclosures [Abstract]

Schedule of Cash, Cash Equivalents and Investments

The following tables summarize the estimated value of cash, cash equivalents and restricted cash (in thousands):


	September 30, 2024
	Adjusted Cost		Estimated Fair Value		Cash and cash equivalents		Restricted cash
Cash	$	1,834	$	1,834	$	1,834	$	—
Level 1:
Money market funds	12,206		12,206		8,645		3,561
Subtotal	12,206		12,206		8,645		3,561






Total	$	14,040	$	14,040	$	10,479	$	3,561


	December 31, 2023
	Adjusted Cost		Estimated Fair Value		Cash and cash equivalents		Restricted cash
Cash	$	4,205	$	4,205	$	4,205	$	—
Level 1:
Money market funds	35,243		35,243		31,721		3,522
Subtotal	35,243		35,243		31,721		3,522






Total	$	39,448	$	39,448	$	35,926	$	3,522

Schedule of Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation

The following table presents a summary of the changes in the fair value of the GeneFab Note Receivable (in thousands):


	Note Receivable
Fair value as of December 31, 2023	$	17,240
Change in fair value included in other income (expense)	(17,240)
Fair value as of September 30, 2024	$	—

The following table presents a summary of the changes in the fair value of the GeneFab Economic Share (in thousands):


	GeneFab Economic Share
Fair value as of December 31, 2023	$	1,816

Change in fair value included in other income (expense)	$	(1,816)
Fair value as of September 30, 2024	$	—

Schedule of Changes in Fair Value of Level 3 Financial Instruments

The following table presents a summary of the changes in the fair value of the GeneFab Option (in thousands):


	GeneFab Option
Fair value as of December 31, 2023	$	(6,331)
Change in fair value included in other income (expense)	6,331
Fair value as of September 30, 2024	$	—

Schedule of Fair Value Measurement Inputs and Valuation Techniques

The significant assumptions utilized in the valuation are described below:


	December 31,
	2023
Current stock price	$	6.60
Expected volatility	98.1		%
Risk-free interest rate	4.12		%
Expected term (years)	2.5

The significant assumptions utilized in the valuation as of December 31, 2023 are described below:


	December 31,
	2023
GeneFab equity value	$	35,448
Volatility	65.8		%
Risk free rate	3.93		%
Expected term	4.0

- Definition

Tabular disclosure of the fair value measurement of assets using significant unobservable inputs (Level 3), a reconciliation of the beginning and ending balances, separately presenting changes during the period attributable to the following: (1) total gains or losses for the period (realized and unrealized), segregating those gains or losses included in earnings (or changes in net assets) and gains or losses recognized in other comprehensive income (loss), and a description of where those gains or losses included in earnings (or changes in net assets) are reported in the statement of income (or activities); (2) purchases, sales, issues, and settlements (each type disclosed separately); and (3) transfers in and transfers out of Level 3 (for example, transfers due to changes in the observability of significant inputs), by class of asset.

+ References + Details

Summary of Significant Accounting Policies	9 Months Ended
Summary of Significant Accounting Policies	Sep. 30, 2024
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies Basis of Presentation The accompanying condensed consolidated financial statements have been prepared in conformity with U.S. GAAP and the rules and regulations of the Securities and Exchange Commission (“SEC”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). The condensed consolidated financial statements include the accounts of Senti Biosciences, Inc., and its wholly-owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. The Company has one business activity and operates in one reportable segment within continuing operations. All long-lived assets of the Company are maintained in the United States. The Company determined that the assets sold to GeneFab in August 2023 met the criteria for presentation as a discontinued operation. As a result, the Company has retrospectively restated its condensed consolidated statements of operations for the three and nine months ended September 30, 2023 to reflect the operating results related to the disposed business in discontinued operations. The Company has chosen not to segregate the cash flows of the disposed business in the condensed consolidated statements of cash flows. Supplemental disclosures related to discontinued operations for the statements of cash flows have been provided in Note 3. GeneFab Transaction. Unless otherwise specified, the disclosures in these condensed consolidated financial statements refer to continuing operations only. Reverse Stock Split On July 17, 2024, the Company effected a 1 for 10 reverse stock split of its common stock (the “Reverse Stock Split”). The par value per share and the number of authorized shares were not adjusted as a result of the Reverse Stock Split. The shares of common stock underlying outstanding stock options and other equity instruments were proportionately reduced and the respective exercise prices, if applicable, were proportionately increased in accordance with the terms of the agreements governing such securities. In addition, the shares available for grants under the Company’s incentive plans were adjusted as a result of the Reverse Stock Split. All references to common stock, options to purchase common stock, outstanding common stock warrants, common stock share data, per share data, and related information contained in the condensed consolidated financial statements have been retrospectively adjusted to reflect the effect of the Reverse Stock Split for all periods presented. No fractional shares were issued as a result of the reverse stock split, as fractional shares of Common Stock were rounded down to the nearest whole share. Refer to Note 7. Stockholders’ Equity, for additional information related to the reverse stock split. Unaudited Interim Condensed Consolidated Financial Statements The accompanying interim condensed consolidated financial statements and the related footnote disclosures are unaudited. These unaudited interim condensed consolidated financial statements have been prepared on the same basis as the audited consolidated financial statements, and in management’s opinion, include all adjustments, consisting of only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2024 and its results of operations for the three months ended September 30, 2024 and 2023, and cash flows for the nine months ended September 30, 2024 and 2023. The results of operations for the three and nine months ended September 30, 2024 are not necessarily indicative of the results to be expected for the year ending December 31, 2024 or any other period. The December 31, 2023 year-end condensed consolidated balance sheet was derived from audited consolidated financial statements but does not include all disclosures from the audited consolidated financial statements. Certain information and footnote disclosures normally included in consolidated financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to such rules and regulations. Accordingly, these condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2023 and the related notes included in the Company’s Form 10-K, filed with the SEC on March 21, 2024, which provides a more complete discussion of the Company’s accounting policies and certain other information. Other than the policy included below, there have been no material changes to the Company’s significant accounting policies as of and for the three and nine months ended September 30, 2024, as compared to the significant accounting policies described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2023, included in the Form 10-K filed with SEC on March 21, 2024. California Institute for Regenerative Medicine Grant On August 3, 2024, the Company executed an agreement with the California Institute for Regenerative Medicine (“CIRM”) for a total grant award of $8.0 million (“CIRM Grant”) in support of the research project related to the ongoing clinical development of SENTI-202. As the Company has the option to convert the CIRM Grant to a loan and thus may be required to repay some or all of the amounts awarded by CIRM, the Company accounted for this award as a liability. Given the uncertainty in amounts due upon repayment, the Company has recorded amounts received without any discount or interest recorded, and upon determination of amounts that would become due, the Company will adjust accordingly. Refer to Note 8. CIRM Grant, for further details of the CIRM Grant. Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, the valuation of stock-based awards, the accrual for research and development expenses, the valuation of GeneFab Option, the valuation of GeneFab Economic Share, the valuation of the GeneFab Note Receivable, the discount rate used to discount future cash flows for the impairment of long-lived assets, and the determination of the incremental borrowing rate. The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances dictate. Actual results could differ from those estimates. Concentration of Credit Risk Financial instruments that potentially subject the Company to a significant concentration of credit risk consist of cash, cash equivalents and restricted cash are maintained in checking and money market accounts at multiple financial institutions, which at times, may exceed federally insured limits. As of September 30, 2024 and 2023, the Company has not experienced any credit losses in such accounts or investments. As of September 30, 2024, the Company has prepaid future manufacturing and research services of $3.9 million under an agreement with GeneFab for certain development and manufacturing services agreement which are recorded in GeneFab prepaid expenses - related party in the condensed consolidated balance sheets and $1.1 million receivable related to general and administrative services provided under the transition services agreement which are recorded in GeneFab receivable - related party in the condensed consolidated balance sheets . The prepaid expenses and receivable balances from GeneFab potentially subject the Company to a significant concentration of credit risk if the Company is unable to realize these balances. Refer to Note 3. GeneFab Transaction, for further details of the GeneFab transaction. Recent Accounting Standards In November 2023, the FASB issued ASU No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires an enhanced disclosure of significant segment expenses on an annual and interim basis. This guidance is effective for annual periods beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. Upon adoption, the guidance should be applied retrospectively to all prior periods presented in the financial statements. The Company is currently evaluating the potential impact of adopting this new guidance on its condensed consolidated financial statements and related disclosures. In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures, which improves income tax disclosures by requiring consistent categories and greater disaggregation of information in the effective tax rate reconciliation and income taxes paid disaggregated by jurisdiction. It also includes certain other amendments to improve the effectiveness of income tax disclosures. This guidance is effective for annual periods beginning after December 15, 2024. Early adoption is permitted. Upon adoption, the guidance can be applied prospectively or retrospectively. The Company is currently evaluating the potential impact of adopting this new guidance on its condensed consolidated financial statements and related disclosures. The Company believes that the impact of recently issued accounting standards that are not yet effective will not be material to its financial position or results of operations upon adoption.

Other Financial Statement information - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Property, Plant and Equipment [Line Items]
Depreciation			$ 2,901	$ 2,569
Continuing Operations
Property, Plant and Equipment [Line Items]
Depreciation	$ 900	$ 1,300	$ 2,900	$ 2,600

Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details) - shares	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	3,149,595	3,387,061	3,149,595	3,387,061
Stock options to purchase common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	921,334	1,191,693	921,334	1,191,693
Unvested early exercised options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	1,688	6,752	1,688	6,752
Restricted stock units outstanding
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	56,423	25,272	56,423	25,272
Performance stock units outstanding
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	106,806	0	106,806	0
Contingent earnout common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	100,000	200,000	100,000	200,000
GeneFab Option (Note 3)
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total	1,963,344	1,963,344	1,963,344	1,963,344

GeneFab Transaction - Narrative (Details)		3 Months Ended		9 Months Ended		12 Months Ended
GeneFab Transaction - Narrative (Details)	Aug. 07, 2023 USD ($) employee $ / shares shares	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Dec. 31, 2023 USD ($)
Related Party Transaction [Line Items]
Impairment of long-lived assets		$ 313,000	$ 25,691,000	$ 313,000	$ 25,691,000
Current liabilities of discontinued operations		0		0		$ 243,000
Fair Value, Inputs, Level 3
Related Party Transaction [Line Items]
Disposal group, including discontinued operation, consideration	$ 37,300,000
Contingent Consideration Receivable \| Fair Value, Inputs, Level 3
Related Party Transaction [Line Items]
Fair value of asset	1,800,000
GeneFab
Related Party Transaction [Line Items]
Consideration received in collaborative development agreement	37,800,000
Upfront payment under research collaboration and license agreement	18,900,000
Variable consideration	18,900,000
Notes receivable at fair value	16,600,000
Prepayments for manufacturing and research activities	$ 18,900,000
Prepaid expenses		3,900,000		3,900,000
Employment offer, number of employees \| employee	45
Option, maximum purchase amount (in shares) \| shares	1,963,344
Option, maximum worth	$ 20,000,000.0
Option, exercise price (in dollars per share) \| $ / shares	$ 10.18670
Option, installments, percentage of stock outstanding (in percent)	19.90%
Revenue, remaining performance obligation, variable consideration, percentage of realized gains	10.00%
GeneFab \| Discontinued Operations, Disposed of by Sale \| Non-Oncology Business
Related Party Transaction [Line Items]
Gain on disposal of business			$ 21,861,000		$ 21,861,000	21,900,000
Assets sold						5,500,000
Current assets of discontinued operations		0		0		0
Current liabilities of discontinued operations		0		0		200,000
GeneFab \| Contingent Consideration Receivable \| Fair Value, Inputs, Level 3
Related Party Transaction [Line Items]
Fair value of asset		0		0		$ 1,816,000
GeneFab \| Equity Option
Related Party Transaction [Line Items]
GeneFab Option - related party		$ 9,600,000		$ 9,600,000

Other Financial Statement information - Schedule of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands	Sep. 30, 2024	Dec. 31, 2023
Related Party Transaction [Line Items]
Prepaid expenses (including prepaid rent)	$ 1,481	$ 2,546
Deposits	357	42
Other	8	195
Nonrelated Party
Related Party Transaction [Line Items]
Prepaid expenses and other current assets	$ 1,846	$ 2,783

Other Financial Statement information (Tables)

9 Months Ended

Sep. 30, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Prepaid expenses (including prepaid rent)	$	1,481	$	2,546
Deposits	357		42

Other	8		195
Total prepaid expenses and other current assets	$	1,846	$	2,783

Schedule of Property and Equipment, Net

Property and equipment, net consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Leasehold improvements	$	22,648	$	22,648
Lab equipment	7,568		8,186
Furniture and fixtures	331		326
Computer equipment and software	299		360

Property and equipment at cost	30,846		31,520
Less: accumulated depreciation	(8,628)		(6,182)
Property and equipment, net	$	22,218	$	25,338

Schedule of Accrued Expenses and Other Liabilities

Accrued expenses and other liabilities consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Accrued employee-related expenses	$	1,571	$	3,555

Accrued professional and service fees other	1,369		2,363
Other accrued expenses	38		9
Total accrued expenses and other current liabilities	$	2,978	$	5,927

Other Financial Statement information

9 Months Ended

Sep. 30, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Other Financial Statement information

Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Prepaid expenses (including prepaid rent)	$	1,481	$	2,546
Deposits	357		42

Other	8		195
Total prepaid expenses and other current assets	$	1,846	$	2,783

Property and Equipment, Net

Property and equipment, net consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Leasehold improvements	$	22,648	$	22,648
Lab equipment	7,568		8,186
Furniture and fixtures	331		326
Computer equipment and software	299		360

Property and equipment at cost	30,846		31,520
Less: accumulated depreciation	(8,628)		(6,182)
Property and equipment, net	$	22,218	$	25,338

Depreciation totaled $0.9 million and $1.3 million for the three months ended September 30, 2024 and 2023, respectively and $2.9 million and $2.6 million for the nine months ended September 30, 2024 and 2023, respectively.

Accrued Expenses and Other Current Liabilities

Accrued expenses and other liabilities consisted of the following (in thousands):


	September 30,		December 31,
	2024		2023
Accrued employee-related expenses	$	1,571	$	3,555

Accrued professional and service fees other	1,369		2,363
Other accrued expenses	38		9
Total accrued expenses and other current liabilities	$	2,978	$	5,927

Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2024

Share-Based Payment Arrangement [Abstract]

Schedule of Share-Based Payment Arrangement, Expensed and Capitalized, Amount

Total stock-based compensation expense was as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
General and administrative	$	529	$	2,153	$	978	$	8,474
Research and development	139		334		172		1,154
Total stock-based compensation expense from continuing operations	668		2,487		1,150		9,628
Stock-based compensation expense from discontinued operations	—		(2,078)		—		(2,022)
Total stock-based compensation expense	$	668	$	409	$	1,150	$	7,606

Operating Leases - Schedule of Other Information (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Leases [Abstract]
Operating cash flows net inflows and (outflows) from operating lease	$ (5,412)	$ (2,449)
Right-of-use assets obtained in exchange for operating lease obligations (including remeasurement of right-of-use assets and lease liabilities due to changes in the timing of receipt of lease incentives)	$ 0	$ 13
Weighted-average remaining lease term (years)	6 years 10 months 24 days	7 years 7 months 6 days
Weighted-average discount rate (in percent)	9.20%	9.20%

Income Tax (Details) - USD ($)	3 Months Ended		9 Months Ended
Income Tax (Details) - USD ($)	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Income Tax Disclosure [Abstract]
Income tax provision (benefit)	$ 0	$ 0	$ 0	$ 0
Current income tax liability	$ 0		$ 0

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 270
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482964/270-10-50-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 32
-Subparagraph (ee)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-32

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-12

Reference 4: http://www.xbrl.org/2003/role/exampleRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 231
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482663/740-10-55-231

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483443/250-10-50-9

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 6.I.7)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479360/740-10-S99-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 8
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483443/250-10-50-8

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-10

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 22
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 944
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(9))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477250/944-220-S99-1

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
-Section 45
-Paragraph 2
-Subparagraph (a)
-SubTopic 20
-Topic 740
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482659/740-20-45-2

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h))
-SubTopic 10
-Topic 235
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1

+ Details

Subsequent Events	9 Months Ended
Subsequent Events	Sep. 30, 2024
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events On October 21, 2024, the Company notified the Nasdaq Stock Market (“Nasdaq”) that the Company is not in compliance with the audit committee requirement under Nasdaq Listing Rule 5605(c)(2)(A) due to the Company having only two members on its audit committee solely due to a vacancy resulting from Susan Berland’s resignation from the Board effective June 11, 2024. On October 22, 2024, the Company received a notice (the “Notice”) from Nasdaq indicating that the Company is no longer compliant with the audit committee requirements as set forth in Nasdaq Listing Rule 5605, the Company has until December 9, 2024 to regain compliance as provided in Nasdaq Listing Rule 5605(c)(4) which defines the cure period. The Company is evaluating the membership of the audit committee and is working to regain compliance with the Nasdaq Listing Rule 5605 prior to the expiration of the applicable cure period. The Notice has no immediate effect on the listing or trading of the Company’s common stock on the Nasdaq Capital Market. On November 1, 2024, the Company received a $2.5 million payment from CIRM in relation to a milestone achieved in August 2024. Refer to Note 8. CIRM Grant, for additional details regarding the CIRM grant and related milestone payments.

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2024	Dec. 31, 2023
Statement of Financial Position [Abstract]
Preferred stock, par value per share (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, authorized (in shares)	10,000,000	10,000,000
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Common stock, par or stated value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, authorized (in shares)	500,000,000	500,000,000
Common stock, issued (in shares)	4,586,957	4,569,900
Common stock, outstanding (in shares)	4,586,957	4,569,900

Stockholders’ Equity - Narrative (Details)				3 Months Ended		9 Months Ended
Stockholders’ Equity - Narrative (Details)	Jul. 17, 2024 $ / shares	Aug. 31, 2022 USD ($) shares	Jun. 08, 2022 tranche $ / shares shares	Sep. 30, 2024 USD ($) vote $ / shares shares	Sep. 30, 2023 USD ($) shares	Sep. 30, 2024 USD ($) vote $ / shares shares	Sep. 30, 2023 USD ($) shares	Dec. 31, 2023 USD ($) $ / shares shares
Class of Stock [Line Items]
Common stock, authorized (in shares)				500,000,000		500,000,000		500,000,000
Common stock, par or stated value (in dollars per share) \| $ / shares	$ 0.0001			$ 0.0001		$ 0.0001		$ 0.0001
Number of votes per common stock \| vote				1		1
Cash dividends declared and paid, common stock \| $						$ 0
Stock split ratio, common stock	0.10
Preferred stock, par value per share (in dollars per share) \| $ / shares				$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, outstanding (in shares)				0		0		0
Preferred stock, issued (in shares)				0		0		0
Preferred stock, authorized (in shares)				10,000,000		10,000,000		10,000,000
Maximum contingent earnout (in shares)			200,000
Number of tranches of contingent earnout shares \| tranche			2
Number of contingent earnout shares per tranche (in shares)			100,000
Number of trading days (in days)			20 days
Consecutive trading days (in days)			30 days
Change in fair value of contingent earnout liability \| $				$ 0	$ 0	$ 0	$ (207,000)
Contingent earnout liability (less than) \| $				$ 100,000		$ 100,000		$ 100,000
Contingent Consideration, Tranche One
Class of Stock [Line Items]
Closing stock price to trigger contingent earnout shares (in dollars per share) \| $ / shares			$ 150.00
Term (in years)			2 years
Contingent Consideration, Tranche Two
Class of Stock [Line Items]
Closing stock price to trigger contingent earnout shares (in dollars per share) \| $ / shares			$ 200.00
Term (in years)			3 years
Common Stock Purchase Agreement
Class of Stock [Line Items]
Number of shares issued (in shares)				3,593		3,593
Common Stock \| Common Stock Purchase Agreement
Class of Stock [Line Items]
Maximum proceeds purchase agreement \| $		$ 50,000,000.0
Term of agreement (in months)		36 months
Number of shares issued, threshold (in shares)		872,704
Shares issued in transaction, threshold (in percent)		19.99%
Trading volume available for purchase, threshold (in percent)		20.00%
Purchase price, threshold \| $		$ 3,000,000.0
Number of shares issued, consideration (in shares)		10,000
Document preparation fees \| $		$ 400,000
Number of shares issued (in shares)		143,593			0		0
Aggregate purchase price \| $						$ 1,200,000
Common Stock \| Common Stock Purchase Agreement \| Measurement Input, Discount Rate
Class of Stock [Line Items]
Discount rate (in percent)		3.00%

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Revenue
Contract revenue	$ 0	$ 255,000	$ 0	$ 1,978,000
Grant income	0	83,000	0	583,000
Total revenue	0	338,000	0	2,561,000
Operating expenses
Research and development (including related party cost of $3,790 and $1,186 for the three months ended September 30, 2024 and 2023, respectively, and $11,059 and $1,186 for the nine months ended September 30, 2024 and 2023, respectively)	8,655,000	9,092,000	26,584,000	23,028,000
General and administrative	6,247,000	9,431,000	17,975,000	27,871,000
Impairment of long-lived assets	313,000	25,691,000	313,000	25,691,000
Total operating expenses	15,215,000	44,214,000	44,872,000	76,590,000
Loss from operations	(15,215,000)	(43,876,000)	(44,872,000)	(74,029,000)
Other income (expense)
Interest income, net	150,000	583,000	718,000	2,438,000
Change in fair value of contingent earnout liability	0	0	0	207,000
GeneFab sublease income - related party	1,657,000	899,000	4,705,000	899,000
Other income (expense)	(11,000)	(14,000)	(6,000)	(26,000)
Total other income (expense), net	(13,651,000)	7,261,000	(7,308,000)	9,311,000
Net loss from continuing operations	(28,866,000)	(36,615,000)	(52,180,000)	(64,718,000)
Net income from discontinued operations	0	21,692,000	0	12,376,000
Net loss	(28,866,000)	(14,923,000)	(52,180,000)	(52,342,000)
Other comprehensive loss
Unrealized loss on investments	0	0	0	(1,000)
Comprehensive loss	$ (28,866,000)	$ (14,923,000)	$ (52,180,000)	$ (52,343,000)
Net loss per share, basic and diluted
Net loss per share from continuing operations, basic (in dollars per share)	$ (6.31)	$ (8.24)	$ (11.41)	$ (14.62)
Net loss per share from continuing operations, diluted (in dollars per share)	(6.31)	(8.24)	(11.41)	(14.62)
Net income per share from discontinued operations, basic (in dollars per share)	0	4.88	0	2.80
Net income per share from discontinued operations, diluted (in dollars per share)	0	4.88	0	2.80
Net loss per share, basic (in dollars per share)	(6.31)	(3.36)	(11.41)	(11.82)
Net loss per share, diluted (in dollars per share)	$ (6.31)	$ (3.36)	$ (11.41)	$ (11.82)
Weighted-average shares outstanding, basic (in shares)	4,577,122	4,447,223	4,573,307	4,427,458
Weighted-average shares outstanding, diluted (in shares)	4,577,122	4,447,223	4,573,307	4,427,458
Related Party
Operating expenses
Research and development (including related party cost of $3,790 and $1,186 for the three months ended September 30, 2024 and 2023, respectively, and $11,059 and $1,186 for the nine months ended September 30, 2024 and 2023, respectively)	$ 3,790,000	$ 1,186,000	$ 11,059,000	$ 1,186,000
GeneFab Note Receivable
Other income (expense)
Change in fair value	(17,435,000)	287,000	(17,240,000)	287,000
GeneFab Economic Share
Other income (expense)
Change in fair value	(398,000)	(123,000)	(1,816,000)	(123,000)
GeneFab Option (Note 3)
Other income (expense)
Change in fair value	$ 2,386,000	$ 5,629,000	$ 6,331,000	$ 5,629,000

Operating Leases - Schedule of Total Lease Cost (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Leases [Abstract]
Operating lease cost	$ 1,312	$ 1,323	$ 3,943	$ 3,952
Short-term lease cost	9	8	26	64
Variable lease cost	268	272	771	894
Total lease cost	$ 1,589	$ 1,603	$ 4,740	$ 4,910

Net Loss Per Share (Tables)

9 Months Ended

Sep. 30, 2024

Earnings Per Share [Abstract]

Schedule of Earnings Per Share, Basic and Diluted

A reconciliation of net loss available to common stockholders and the number of shares in the calculation of basic and diluted loss per share is as follows:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Net loss from continuing operations	$	(28,866)	$	(36,615)	$	(52,180)	$	(64,718)
Net income from discontinued operations	—		21,692		—		12,376
Net loss	$	(28,866)	$	(14,923)	$	(52,180)	$	(52,342)

Weighted-average shares used in computing net loss per share, basic and diluted	4,577,122		4,447,223		4,573,307		4,427,458

Net loss per share from continuing operations, basic and diluted	$	(6.31)	$	(8.24)	$	(11.41)	$	(14.62)
Net income per share from discontinued operations, basic and diluted	—		4.88		—		2.80
Net loss per share attributable to common stockholders, basic and diluted	$	(6.31)	$	(3.36)	$	(11.41)	$	(11.82)

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

The following potential common stock securities were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods presented because including them would have been anti-dilutive (on an as-converted basis):


	Three Months Ended September 30,		Nine Months Ended September 30,
	2024	2023	2024	2023

Stock options to purchase common stock	921,334	1,191,693	921,334	1,191,693
Unvested early exercised options	1,688	6,752	1,688	6,752
Restricted stock units outstanding	56,423	25,272	56,423	25,272
Performance stock units outstanding	106,806	—	106,806	—
Contingent earnout common stock	100,000	200,000	100,000	200,000
GeneFab Option (Note 3)	1,963,344	1,963,344	1,963,344	1,963,344
Total	3,149,595	3,387,061	3,149,595	3,387,061

Related Parties (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended		9 Months Ended
Related Parties (Details) - USD ($) $ in Thousands	May 21, 2021	Jan. 31, 2023	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Dec. 31, 2023	Aug. 07, 2023
Related Party Transaction [Line Items]
Sublease income, including variable costs			$ 1,657	$ 0	$ 4,705	$ 0
Research and development			8,655	9,092	26,584	23,028
Senti Biosciences, Inc. \| Bayer
Related Party Transaction [Line Items]
Common stock percentage							13.00%
Related Party
Related Party Transaction [Line Items]
Accounts receivable			1,113		1,113		$ 17,592
Research and development			3,790	$ 1,186	11,059	$ 1,186
BlueRock \| Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Related Party Transaction [Line Items]
Expected costs and expenses incurred	$ 10,000
Term of agreement (in years)	3 years
Seer, Inc. \| Lab Automation Equipment Purchase \| Related Party
Related Party Transaction [Line Items]
Related party transaction, amount of transaction		$ 200
Expenses incurred from transaction, payment term (in years)		2 years
GeneFab
Related Party Transaction [Line Items]
Prepayments for manufacturing and research activities								$ 18,900
Accounts receivable			1,100		1,100
GeneFab \| Related Party
Related Party Transaction [Line Items]
Prepayments for manufacturing and research activities			3,900		3,900			$ 18,900
GeneFab \| Related Party \| Alameda
Related Party Transaction [Line Items]
Sublease income, including variable costs					4,700
GeneFab \| Costs Incurred On Behalf Of GeneFab \| Related Party
Related Party Transaction [Line Items]
Accounts receivable			900		900
Research and development			$ 3,800		$ 11,100

Fair Value Measurements -Schedule of the Estimated Fair Value of Cash, Cash Equivalents, Restricted Cash, And Short-Term Investments (Details) - USD ($) $ in Thousands	Sep. 30, 2024	Dec. 31, 2023	Sep. 30, 2023	Dec. 31, 2022
Debt Securities, Available-for-Sale [Line Items]
Total	$ 14,040	$ 39,448	$ 45,828	$ 60,987
Cash and cash equivalents
Debt Securities, Available-for-Sale [Line Items]
Total	10,479	35,926
Restricted cash
Debt Securities, Available-for-Sale [Line Items]
Total	3,561	3,522
Level 1
Debt Securities, Available-for-Sale [Line Items]
Cash	1,834	4,205
Cash equivalents and restricted cash	12,206	35,243
Level 1 \| Cash and cash equivalents
Debt Securities, Available-for-Sale [Line Items]
Cash	1,834	4,205
Cash equivalents and restricted cash	8,645	31,721
Level 1 \| Restricted cash
Debt Securities, Available-for-Sale [Line Items]
Cash	0	0
Cash equivalents and restricted cash	3,561	3,522
Level 1 \| Money market funds
Debt Securities, Available-for-Sale [Line Items]
Cash equivalents and restricted cash	12,206	35,243
Level 1 \| Money market funds \| Cash and cash equivalents
Debt Securities, Available-for-Sale [Line Items]
Cash equivalents and restricted cash	8,645	31,721
Level 1 \| Money market funds \| Restricted cash
Debt Securities, Available-for-Sale [Line Items]
Cash equivalents and restricted cash	$ 3,561	$ 3,522

- Definition

Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Excludes cash and cash equivalents within disposal group and discontinued operation.

+ References + Details

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Operating Leases - Schedule of Sublease Income (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Leases [Abstract]
Sublease income - base rent	$ 1,314	$ 0	$ 3,757	$ 0
Sublease income - variable and other	343	0	948	0
Total sublease income	$ 1,657	$ 0	$ 4,705	$ 0

Cover - shares	9 Months Ended
Cover - shares	Sep. 30, 2024	Nov. 08, 2024
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Sep. 30, 2024
Document Transition Report	false
Entity File Number	001-40440
Entity Registrant Name	Senti Biosciences, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	86-2437900
Entity Address, Address Line One	2 Corporate Drive, First Floor
Entity Address, City or Town	South San Francisco
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94080
City Area Code	(650)
Local Phone Number	239-2030
Title of 12(b) Security	Common stock, par value $0.0001 per share
Trading Symbol	SNTI
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	true
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		4,588,645
Entity Central Index Key	0001854270
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q3
Amendment Flag	false

Commitment and Contingencies	9 Months Ended
Commitment and Contingencies	Sep. 30, 2024
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Research and Development Agreements The Company enters into various agreements in the ordinary course of business, such as those with suppliers, clinical research organizations and contract manufacturing organizations. These agreements provide for termination at the request of either party, generally with less than one-year notice and are, therefore, cancellable contracts and, if cancelled, are not anticipated to have a material effect on the Company’s condensed consolidated financial condition, results of operations, or cash flows. Leases The Company’s corporate headquarters and an additional office are located in South San Francisco, California. The lease has an initial term of eight years expiring in 2027, with an option to renew for an additional eight years unless canceled by either party thereafter. On June 3, 2021, the Company entered into a lease agreement for a new cGMP facility in Alameda, California to support planned initial clinical trials for its product candidates. The lease will expire in 2032. Refer to Note 6. Operating Leases, for further details on the leases. Legal Proceedings The Company is subject to claims and assessments from time to time in the ordinary course of business but does not believe that any such matters, individually or in the aggregate, will have a material adverse effect on the Company’s financial position, results of operations, or cash flows. The Company was not subject to any material legal proceedings during the nine months ended September 30, 2024 and 2023. Guarantees and Indemnifications In the ordinary course of business, the Company enters into agreements that contain a variety of representations and provide for general indemnification. Pursuant to such agreements, the Company may indemnify, hold harmless and defend an indemnified party for losses suffered or incurred by the indemnified party. Some of the provisions will limit losses to those arising from third-party actions. In some cases, the indemnification will continue after the termination of the agreement. The maximum potential amount of future payments the Company could be required to make under these provisions is not determinable. The Company has never incurred material costs to defend lawsuits or settle claims related to these indemnification provisions and has never accrued any liabilities related to such obligations in its condensed consolidated financial statements. The Company has also entered into indemnification agreements with its directors and officers that may require the Company to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers to the fullest extent permitted by Delaware corporate law. The Company currently has directors’ and officers’ insurance. As of September 30, 2024, and December 31, 2023, the Company did not have any material indemnification claims that were probable or reasonably possible, and consequently, has not recorded any related liabilities.

Revenue	9 Months Ended
Revenue	Sep. 30, 2024
Revenue From and Not From Contracts [Abstract]
Revenue	Revenue The Company’s revenue earned in the three and nine months ended September 30, 2023 consists of amounts received related to research services provided. The Company earned no revenue in the three and nine months ended September 30, 2024. Contract Revenue In April 2021, the Company entered into a research collaboration and license agreement with Spark Therapeutics, Inc. (“Spark”). Under the agreement, the Company will be responsible for a research program, which includes designing, building and testing five cell type specific-synthetic promoters for use in developing certain gene therapies using the Company’s proprietary technology. The Company received an upfront payment from Spark of $3.0 million and Spark is obligated to reimburse the Company for costs and expenses incurred for the research program. The Company expected to complete the research program over a two-year period. The Company assessed this agreement in accordance with ASC 606, Revenue Recognition (“ASC 606”) and concluded that the contract counterparty, Spark, is a customer. The Company identified only one combined performance obligation in the agreement, which is to perform research services, the related joint research plan and committees for the five specified promoters. The Company determined that the research activities for each of the five promoters are not distinct given there is one single research plan that is performed by the same research team and research results for one promoter may provide insights for other promoters. Pursuant to the agreement, once the research program is completed and the Company delivers a data package to Spark, Spark has 24 months (the “Evaluation Period”) to determine whether Spark will exercise its options to obtain field-limited, royalty-bearing licenses to develop, manufacture and commercialize promoters corresponding to each of the five specified promoters being researched. For each licensed promoter option that is exercised, the Company is eligible to receive a license fee, potential research, development and commercial milestone payments and royalties on product sales. Spark may generally terminate the agreement upon 90 days prior written notice or 180 days prior written notice if the licensed promoter is in clinical trials or is being commercialized at the time of termination. The Company evaluated Spark’s optional rights to license, develop, manufacture and commercialize each of the promoter profiles to determine whether they provide Spark with any material rights to purchase the promoter licenses at an incremental discount. The Company’s proprietary technology used to develop the promoters is in the early stages of development, so technological feasibility and probability of developing a product is highly uncertain. As a result, determining the SSP for the optional rights is subject to significant judgment. Given the subjectivity associated with determining the SSP for the right to a future license related to unproven technology at contract inception, the Company also evaluated whether the contract consideration associated with the research services represents the SSP for those services. The Company determined the transaction price, inclusive of the upfront payment and reimbursement of costs and expenses incurred for the research program, is commensurate with SSP for the research being conducted given the specialized nature and reliance on proprietary technology. Based on the Company’s assessment of the optional consideration and the qualitative factors of feasibility and probability of development combined with the quantitative assessment that research services are priced at their SSP, the Company concluded that the license option does not provide Spark with an incremental discount and therefore does not constitute a material right. The transaction price associated with the research services in this agreement consists of the fixed upfront amount of $3.0 million and variable consideration. For Spark collaboration agreement, the Company recognized the transaction price as research and development services were provided, using a cost-based input method to measure the progress toward completion of its performance obligation and to calculate the corresponding amount of revenue to recognize each period. The Company believes that the cost-based input method is the best measure of progress because other measurements would not reflect how the Company transfers the control related to the performance obligation to our customers. In December 2022 and May 2023, the Company amended the research collaboration and license agreement with Spark to allow for an increase in budget and an extension of the research program. As there were no changes to performance obligations and the services to be provided are not distinct from those already transferred, the transactions were accounted for as a contract modifications. In July 2023, the Company completed the research program under the research collaboration and license agreement with Spark and the remaining upfront payment was recognized. In November 2023, the Company entered into a Collaboration and Option Agreement with Celest Therapeutics (Shanghai) Co. Ltd. (“Celest”). Subject to the terms and conditions of the Agreement, the Company and Celest will enter into a collaboration under which Celest will lead a pilot trial of a candidate product for the SENTI-301A program in mainland China, with certain technical support from the Company. In addition, the Company agreed to grant an exclusive option to enter a license agreement with Celest to research, develop, manufacture and commercialize SENTI-301A in mainland China, Hong Kong, Macau, and Taiwan. Outside of these jurisdictions, the Company would retain its rights in the SENTI-301A program. Pursuant to the Agreement, with the exercise of the option and entering into a license agreement, the Company may become eligible to receive certain option exercise fee and milestone payments, in an aggregate amount of $156.0 million, as well as certain tiered royalty payments. For the three and nine months ended September 30, 2023, the Company recorded revenue, which was previously included in deferred revenue at the beginning of each period, of $0.2 million and $0.8 million, respectively. Grant Income SBIR Grant In 2021, the Small Business Innovation Research (“SBIR”) awarded the Company a grant in the amount of $2.0 million over two years subject to meeting certain terms and conditions. The purpose of the grant is to support the further development of SENTI-202 for acute myeloid leukemia towards clinical development. Grant income was recognized when qualified research and development costs were incurred and the Company obtained reasonable assurance that the terms and conditions of the grant were met. In August 2023, the Company completed the research and development project which was the subject of the SBIR grant. For the three and nine months ended September 30, 2023, the Company recorded $0.1 million and $0.6 million grant income, respectively. Entity-wide information During the three months ended September 30, 2023, Customers A and B accounted for 75% and 25% of revenue, respectively. During the nine months ended September 30, 2023, Customers A and B accounted for 77% and 23% of revenue, respectively. All revenues were generated in the United States.

Pay vs Performance Disclosure - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Sep. 30, 2024	Sep. 30, 2023
Pay vs Performance Disclosure
Net loss	$ (28,866)	$ (11,203)	$ (12,111)	$ (14,923)	$ (18,697)	$ (18,722)	$ (52,180)	$ (52,342)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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Reference 30: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iv))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480097/470-10-S99-1B

Reference 31: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(5))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480097/470-10-S99-1B

Reference 32: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 60B
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482689/260-10-45-60B

Reference 33: http://www.xbrl.org/2003/role/disclosureRef
-Topic 205
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 7
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483499/205-20-50-7

Reference 34: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 230
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 28
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482740/230-10-45-28

Reference 35: http://www.xbrl.org/2003/role/disclosureRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1A
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482790/220-10-45-1A

Reference 36: http://www.xbrl.org/2003/role/disclosureRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1B
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482790/220-10-45-1B

Reference 37: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 942
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(22))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478524/942-220-S99-1

+ Details

Revenue - Entity-wide information (Details) - Revenue Benchmark - Customer Concentration Risk	3 Months Ended	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2023
Customer A
Concentration Risk [Line Items]
Percentage of concentration	75.00%	77.00%
Customer B
Concentration Risk [Line Items]
Percentage of concentration	25.00%	23.00%

Condensed Consolidated Statements of Cash Flows - USD ($)	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Cash flows from operating activities
Net loss	$ (52,180,000)	$ (52,342,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	2,901,000	2,569,000
Amortization of operating lease right-of-use assets	1,491,000	1,386,000
Accretion of discount on short-term investments	0	(1,069,000)
Gain on disposal of business	0	(21,862,000)
Change in fair value of contingent earnout liability	0	(207,000)
Impairment of long-lived assets	313,000	25,691,000
Stock-based compensation expense	1,150,000	7,606,000
Loss on sale of property and equipment - related party	107,000	0
Other non-cash charges, net	98,000	(21,000)
Changes in assets and liabilities:
Accounts payable	(442,000)	465,000
Accrued expenses and other current liabilities	(2,702,000)	(1,195,000)
GeneFab sublease deferred income - related party	(350,000)	747,000
Deferred revenue	0	(799,000)
Operating lease liabilities	(2,963,000)	114,000
Other liabilities, net of current portion	113,000	0
Net cash used in operating activities	(27,893,000)	(45,358,000)
Cash flows from investing activities
Purchases of short-term investments	0	(17,990,000)
Maturities of short-term investments	0	60,000,000
Purchases of property and equipment	(15,000)	(12,034,000)
Proceeds from sale of property and equipment	60,000	0
Net cash provided by investing activities	45,000	29,976,000
Cash flows from financing activities
Proceeds from CIRM Grant	2,430,000	0
Proceeds from issuance of common stock under Common Stock Purchase Agreement	10,000	308,000
Principal finance lease payments	0	(85,000)
Net cash provided by financing activities	2,440,000	223,000
Net decrease in cash, cash equivalents and restricted cash	(25,408,000)	(15,159,000)
Cash, cash equivalents, and restricted cash, beginning of period	39,448,000	60,987,000
Cash, cash equivalents, and restricted cash, end of period	14,040,000	45,828,000
Reconciliation of cash, cash equivalents and restricted cash
Cash and cash equivalents	10,479,000	39,430,000
Restricted cash	3,561,000	6,398,000
Total	14,040,000	45,828,000
Supplemental disclosures of noncash investing and financing and items
Purchases of property and equipment in accounts payable and accrued expenses	0	3,000
Receivable in prepaid expenses and other current assets	52,000	0
GeneFab Notes Receivable
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value	17,240,000	(287,000)
GeneFab Economic Share
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value	1,816,000	123,000
GeneFab Option (Note 3)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value	(6,331,000)	(5,629,000)
Nonrelated Party
Changes in assets and liabilities:
Accounts receivable	(53,000)	509,000
Prepaid expenses and other assets	1,116,000	(141,000)
Related Party
Changes in assets and liabilities:
Accounts receivable	(132,000)	(2,602,000)
Prepaid expenses and other assets	$ 10,915,000	$ 1,586,000

Operating Leases - Schedule of Maturities of Operating Lease Liabilities (Details) $ in Thousands	Sep. 30, 2024 USD ($)
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
2024, for the remainder of the year	$ 1,839
2025	7,478
2026	7,712
2027	5,769
2028	4,855
2029	5,000
Thereafter	14,529
Total undiscounted lease payments	47,182
Less imputed interest	(12,576)
Total lease liabilities	34,606
Lessor, Operating Lease, Payment to be Received, Fiscal Year Maturity [Abstract]
2024, for the remainder of the year	1,205
2025	5,339
2026	5,472
2027	5,053
2028	4,891
2029	5,037
Thereafter	13,258
Total undiscounted sublease payments	$ 40,255

Stock-Based Compensation - Narrative (Details) $ in Millions	9 Months Ended
	Sep. 30, 2024 USD ($) shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Unrecognized compensation expense \| $	$ 3.5
2022 Stock Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Authorized for issuance under share-based payment arrangement (in shares)	510,383
2022 Inducement Equity Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Authorized for issuance under share-based payment arrangement (in shares)	172,312
2022 Employee Stock Purchase Plan (the "ESPP")
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Authorized for issuance under share-based payment arrangement (in shares)	79,387
Stock options to purchase common stock
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based payment arrangement, period for recognition (in years)	1 year 7 months 6 days

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480483/718-10-35-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(2)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(ii)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iii)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)(01)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)(02)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)(03)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)(04)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Section 50
-Paragraph 2
-Subparagraph (c)(2)(i)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Paragraph 2
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(2)(iii)(01)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Section 50
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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Reference 20: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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Reference 21: http://www.xbrl.org/2003/role/disclosureRef
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Reference 22: http://www.xbrl.org/2003/role/disclosureRef
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Reference 23: http://www.xbrl.org/2003/role/disclosureRef
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Reference 24: http://www.xbrl.org/2003/role/disclosureRef
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Reference 25: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(ii)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 26: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iii)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 27: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iv)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 28: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(v)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

+ Details

Other Financial Statement information - Schedule of Accrued Expenses and Other Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2024	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accrued employee-related expenses	$ 1,571	$ 3,555
Accrued professional and service fees other	1,369	2,363
Other accrued expenses	38	9
Total accrued expenses and other current liabilities	$ 2,978	$ 5,927

GeneFab Transaction - Schedule of Disposal Groups, Including Discontinued Operations (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Dec. 31, 2023
Operating expenses:
Net income from discontinued operations	$ 0	$ 21,692	$ 0	$ 12,376
GeneFab \| Discontinued Operations, Disposed of by Sale \| Non-Oncology Business
Operating expenses:
Research and development		1,641		9,975
General and administrative		(1,478)		(496)
Total operating expenses		163		9,479
Loss from discontinued operations		(163)		(9,479)
Other expense		(6)		(6)
Gain on disposal of business		21,861		21,861	$ 21,900
Net income from discontinued operations		$ 21,692		12,376
Cash flows from operating activities
Depreciation				185
Stock-based compensation				(2,022)
Investing activities:
Purchases of property and equipment				$ (4,079)

Organization and Description of Business (Details) $ in Thousands		3 Months Ended						9 Months Ended
	Jul. 17, 2024	Sep. 30, 2024 USD ($)	Jun. 30, 2024 USD ($)	Mar. 31, 2024 USD ($)	Sep. 30, 2023 USD ($)	Jun. 30, 2023 USD ($)	Mar. 31, 2023 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Aug. 03, 2024 USD ($)	Dec. 31, 2023 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Cash acquired through reverse recapitalization								$ 302,500
Retained earnings (accumulated deficit)		$ (296,524)						(296,524)			$ (244,344)
Net loss		28,866	$ 11,203	$ 12,111	$ 14,923	$ 18,697	$ 18,722	52,180	$ 52,342
Cash and cash equivalents		$ 10,479			$ 39,430			$ 10,479	$ 39,430		$ 35,926
Stock split ratio, common stock	0.10
California Institute of Regenerative Medicine (“CIRM”) \| Grant
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Grant award										$ 8,000

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

- Definition

Amount of accumulated undistributed earnings (deficit).

+ References + Details

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2024	Dec. 31, 2023
Assets
Cash and cash equivalents	$ 10,479	$ 35,926
Total current assets	17,384	71,200
Restricted cash	3,561	3,522
GeneFab receivable - related party, net of current portion	0	1,119
Property and equipment, net	22,218	25,338
Operating lease right-of-use assets	14,470	16,274
GeneFab Economic Share - related party	0	1,816
Other long-term assets	88	215
Total assets	57,721	119,484
Liabilities and Stockholders’ Equity
Accounts payable	793	1,250
Finance lease liabilities - related party, current portion	103	97
Early exercise liability, current portion	45	135
GeneFab sublease deferred income - related party	639	989
Accrued expenses and other current liabilities	2,978	5,927
Operating lease liabilities	4,486	4,031
Contingent earnout liability	20	0
Current liabilities of discontinued operations	0	243
Total current liabilities	9,064	12,672
Operating lease liabilities, net of current portion	30,120	33,538
GeneFab Option - related party	0	6,331
Other liabilities, net of current portion	2,543	0
Contingent earnout liability, net of current portion	0	20
Early exercise liability, net of current portion	0	10
Total liabilities	41,727	52,571
Commitments and contingencies (Note 13)
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000,000 shares authorized at September 30, 2024 and December 31, 2023; zero shares issued and outstanding at September 30, 2024 and December 31, 2023	0	0
Common stock, $0.0001 par value; 500,000,000 shares authorized at September 30, 2024 and December 31, 2023; 4,586,957 and 4,569,900 shares issued and outstanding at September 30, 2024 and December 31, 2023, respectively	1	1
Additional paid-in capital	312,517	311,256
Accumulated deficit	(296,524)	(244,344)
Total stockholders’ equity	15,994	66,913
Total liabilities and stockholders’ equity	57,721	119,484
Nonrelated Party
Assets
Accounts receivable	74	112
Prepaid expenses	1,846	2,783
Related Party
Assets
Accounts receivable	1,113	17,592
Prepaid expenses	$ 3,872	$ 14,787

Other Financial Statement information - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands	Sep. 30, 2024	Dec. 31, 2023
Property, Plant and Equipment [Line Items]
Property and equipment at cost	$ 30,846	$ 31,520
Less: accumulated depreciation	(8,628)	(6,182)
Property and equipment, net	22,218	25,338
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment at cost	22,648	22,648
Lab equipment
Property, Plant and Equipment [Line Items]
Property and equipment at cost	7,568	8,186
Furniture and fixtures
Property, Plant and Equipment [Line Items]
Property and equipment at cost	331	326
Computer equipment and software
Property, Plant and Equipment [Line Items]
Property and equipment at cost	$ 299	$ 360

Fair Value Measurements - Schedule of Changes in Fair Value of Level 3 Financial Instruments, Assets (Details) - GeneFab - Fair Value, Inputs, Level 3	9 Months Ended
	Sep. 30, 2024 USD ($)
Notes Receivable
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	$ 17,240,000
Change in fair value included in other income (expense)	(17,240,000)
Ending balance	0
Contingent Consideration Receivable
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	1,816,000
Change in fair value included in other income (expense)	(1,816,000)
Ending balance	$ 0

Operating Leases - Narrative (Details)	3 Months Ended		9 Months Ended		12 Months Ended
Operating Leases - Narrative (Details)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Sep. 30, 2024 USD ($) term	Sep. 30, 2023 USD ($)	Dec. 31, 2023 USD ($)	Jul. 12, 2024 USD ($)	Aug. 07, 2023 USD ($)
Lessee, Lease, Description [Line Items]
Total undiscounted sublease payments	$ 40,255,000		$ 40,255,000
Impairment charge	$ 313,000	$ 25,691,000	$ 313,000	$ 25,691,000
Corporate Headquarters
Lessee, Lease, Description [Line Items]
Operating lease, term of contract (in years)	8 years		8 years
Lease renewal term (in years)	8 years		8 years
Corporate Headquarters \| JPMorgan Chase Bank
Lessee, Lease, Description [Line Items]
Letters of credit	$ 500,000		$ 500,000
Corporate Headquarters \| GeneFab
Lessee, Lease, Description [Line Items]
Total undiscounted sublease payments						$ 1,300,000
Corporate Headquarters \| BKPBIOTECH, Inc. and JLSA2 Therapeutics, Inc
Lessee, Lease, Description [Line Items]
Sublease income to be earned			$ 1,000,000
Alameda
Lessee, Lease, Description [Line Items]
Operating lease, term of contract (in years)	11 years		11 years
Lease renewal term (in years)	5 years		5 years
Number of renewal options \| term			2
Tenant improvement allowance received		0		2,000,000.0
Tenant improvement allowance		$ 17,500,000		$ 17,500,000
Tenant improvement allowance utilized					$ 17,500,000
Alameda \| JPMorgan Chase Bank
Lessee, Lease, Description [Line Items]
Letters of credit	$ 2,800,000		$ 2,800,000
Alameda \| GeneFab
Lessee, Lease, Description [Line Items]
Total undiscounted sublease payments							$ 44,100,000

Operating Leases

9 Months Ended

Sep. 30, 2024

Leases [Abstract]

Operating Leases

Lessee Accounting

The Company’s operating leases are primarily for its corporate headquarters located in South San Francisco, California (“HQ lease”) and for additional office and laboratory space located in Alameda, California (“Alameda lease”). The HQ Lease has an initial term of eight years expiring in 2027, with an option to renew for an additional eight years unless canceled by either party thereafter. The Alameda lease has an initial term of eleven years expiring in 2032, with an option to renew the lease for up to two additional terms of five years. The exercise of these renewal options is not recognized as part of the ROU assets and lease liabilities, as the Company did not conclude, at the commencement date of the leases, that the exercise of renewal options or termination options was reasonably certain. The Alameda lease provided for a tenant improvement allowance of up to $17.5 million for the costs relating to the design, permitting and construction of the improvements, disbursed by the landlord by December 31, 2023. The Company was deemed to be the accounting owner of the tenant improvements primarily because the Company is the principal in the construction and design of the assets, is responsible for costs overruns and retains substantially all economic benefits from the leasehold improvements over their economic lives. Accordingly, the tenant improvement allowance was considered an incentive and was deducted from the initial measurement of the ROU asset and lease liability. The Company estimated the timing of tenant improvement reimbursements at the lease commencement date and upon receipt of the cash incentives, the Company recognized the cash received as an increase in the lease liability.

A summary of total lease costs and other information for the period relating to the Company’s operating leases is as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Operating lease cost	$	1,312	$	1,323	$	3,943	$	3,952
Short-term lease cost	9		8		26		64
Variable lease cost	268		272		771		894
Total lease cost	$	1,589	$	1,603	$	4,740	$	4,910


	Nine Months Ended September 30,
	2024		2023
Other information:
Operating cash flows net inflows and (outflows) from operating lease	$	(5,412)	$	(2,449)
Right-of-use assets obtained in exchange for operating lease obligations (including remeasurement of right-of-use assets and lease liabilities due to changes in the timing of receipt of lease incentives)	$	—	$	13
Weighted-average remaining lease term (years)	6.9		7.6
Weighted-average discount rate	9.2%		9.2%

For the three and nine months ended September 30, 2023, the Company received zero and $2.0 million, respectively, of the $17.5 million tenant improvement allowance. As of December 31, 2023, the Company received the full $17.5 million tenant improvement allowance.

Maturities of the Company’s lease liabilities as of September 30, 2024, were as follows (in thousands):


2024, for the remainder of the year	$	1,839
2025	7,478
2026	7,712
2027	5,769
2028	4,855
2029	5,000
Thereafter	14,529
Total undiscounted lease payments	47,182
Less imputed interest	(12,576)

Total lease liabilities	$	34,606

Letters of Credit

As of September 30, 2024 the Company held a letter of credit with JPMorgan Chase Bank in the amount of approximately $2.8 million related to the Alameda facility and a letter of credit with JPMorgan Chase Bank in the amount of approximately $0.5 million related to our HQ facility lease which are recorded as restricted cash in the condensed consolidated balance sheets as of September 30, 2024 and December 31, 2023.

Lessor Accounting

GeneFab Sublease

In connection with the GeneFab transaction, on August 7, 2023, the Company entered into a sublease with GeneFab to sublease the facility included in the Alameda lease, expiring in September 2032. Total sublease income to be earned from this operating lease, in aggregate, will be approximately $44.1 million over the term of the sublease agreement.

On June 12, 2024, the Company entered into a sublease with GeneFab for a portion of the Company’s corporate headquarter premises in South San Francisco. Total sublease income to be earned from this operating lease, in aggregate, will be approximately $1.3 million over the term of the sublease agreement.

A summary of total sublease income for the period relating to the Company’s operating leases is as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Sublease income - base rent	$	1,314	—		$	3,757	$	—
Sublease income - variable and other	343		—		948		—
Total sublease income	$	1,657	$	—	$	4,705	$	—

The Company records sublease income in other income (expense) in the condensed consolidated statements of operations and comprehensive loss.

Refer to Note 14. Related Parties, for GeneFab related party considerations.

BKPBIOTECH and JLSA2 Therapeutics Sublease

On September 23, 2024, the Company entered into a sublease agreement with BKPBIOTECH, Inc. and JLSA2 Therapeutics, Inc., to sublease a portion of the Company’s corporate headquarter premises in South San Francisco. The sublease commenced on October 7, 2024, and will expire on April 30, 2027. Total sublease income to be earned from this operating lease, in aggregate, will be approximately $1.0 million over the term of the sublease agreement. The sublease contains customary events of default, representations, warranties and covenants.

Pursuant to ASC Topic 842, Leases, the Company concluded that the sublease is a separate lease and it qualifies as an operating lease.

As a result of sublease, the Company identified an impairment indicator related to the HQ Lease. The Company compared the estimated undiscounted cash flows to the carrying value of the asset group, which includes right-of-use assets and leasehold improvements allocable to the sublease. The Company concluded that the carrying value of the asset group was not recoverable as it exceeded the estimated undiscounted cash flows. The Company calculated the amount of impairment using a discounted cash flow model to calculate the fair value of the asset group which incorporated the net identifiable cash flows for the term of sublease, including an estimate for cash flows in the residual period, and an estimated borrowing rate of a market participant subtenant. The impairment charge of $0.3 million was recorded as impairment of long-lived assets in the statement of operations and comprehensive loss for the three months ended September 30, 2024.

Maturities of the Company’s sublease payments for the subleases of both Alameda facility and corporate headquarter premises as of September 30, 2024, were as follows (in thousands):


2024, for the remainder of the year	$	1,205
2025	5,339
2026	5,472
2027	5,053
2028	4,891
2029	5,037
Thereafter	13,258
Total undiscounted sublease payments	$	40,255

Stockholders’ Equity - Schedule of Common Stock Reserved for Future Issuance (Details) - shares	Sep. 30, 2024	Dec. 31, 2023
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	4,640,788	4,483,216
Common Stock Purchase Agreement
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	729,111	732,704
Stock options to purchase common stock
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	921,334	1,158,294
Restricted stock units outstanding
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	56,423	22,528
Performance Stock Units (PSUs) issued and outstanding
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	106,806	0
Common stock shares available for future issuance under equity plans
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	682,695	367,228
Common stock shares available for future issuance under the 2022 Employee Stock Purchase Plan (the "ESPP")
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	79,387	33,632
Contingent earnout common stock
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	100,000	200,000
GeneFab Option (Note 3)
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	1,963,344	1,963,344
Unvested early exercised common stock
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)	1,688	5,486

Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	$ 668	$ 409	$ 1,150	$ 7,606
Continuing Operations
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	668	2,487	1,150	9,628
Discontinued Operations
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	0	(2,078)	0	(2,022)
General and administrative \| Continuing Operations
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	529	2,153	978	8,474
Research and development \| Continuing Operations
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	$ 139	$ 334	$ 172	$ 1,154

GeneFab Transaction (Tables)

9 Months Ended

Sep. 30, 2024

Schedule of Disposal Groups, Including Discontinued Operations

The following table summarizes the condensed operating results of the discontinued operations for the three and nine months ended September 30, 2023 (in thousands):


	Three Months Ended September 30,		Nine months ended September 30,
	2023		2023
Operating expenses:
Research and development	$	1,641	$	9,975
General and administrative	(1,478)		(496)
Total operating expenses	163		9,479
Loss from discontinued operations	(163)		(9,479)
Other expense	(6)		(6)
Gain on disposal of business	21,861		21,861
Net income from discontinued operations	$	21,692	$	12,376

The following table summarizes the condensed cash flow information of the discontinued operations for the nine months ended September 30, 2023 (in thousands):


	Nine months ended September 30,
	2023
Operating activities (noncash adjustments to net income):
Depreciation	$	185
Stock-based compensation	(2,022)

Investing activities:
Purchases of property and equipment	$	(4,079)

- Definition

Tabular disclosure of information related to a disposal group. Includes, but is not limited to, a discontinued operation, disposal classified as held-for-sale or disposed of by means other than sale or disposal of an individually significant component.

+ References

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+ Details

Fair Value Measurements - Narrative (Details) - Fair Value, Inputs, Level 3	Sep. 30, 2024 USD ($)	Dec. 31, 2023 USD ($)	Aug. 07, 2023 USD ($)
Contingent Consideration Receivable
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair value of asset			$ 1,800,000
GeneFab \| Equity Option \| Derivative Financial Instruments, Liabilities
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair value of liability	$ 0	$ (6,331,000)
GeneFab \| Contingent Consideration Receivable
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair value of asset	$ 0	$ 1,816,000
GeneFab \| Measurement Input, Discount Rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Notes receivable, measurement input		0.1253

Fair Value Measurements - Schedule of Changes in Fair Value of Level 3 Financial Instruments, Liabilities (Details) - Fair Value, Inputs, Level 3 - Derivative Financial Instruments, Liabilities - GeneFab - Equity Option $ in Thousands	9 Months Ended
	Sep. 30, 2024 USD ($)
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	$ (6,331)
Change in fair value included in other income (expense)	6,331
Ending balance	$ 0

Organization and Description of Business	9 Months Ended
Organization and Description of Business	Sep. 30, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and Description of Business	Organization and Description of Business Senti Biosciences, Inc. and its subsidiaries (the “Company” or “Senti”), is an early clinical stage biotechnology company developing next-generation cell and gene therapies engineered with its gene circuit platform technologies for patients living with incurable diseases. Senti’s mission is to create a new generation of smarter therapies that can outsmart complex diseases using novel and unprecedented approaches. Senti has built a synthetic biology platform that enables it to program next-generation cell and gene therapies with gene circuits. These gene circuits, which are created from novel and proprietary combinations of DNA sequences, reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. The Company is headquartered in South San Francisco, California. On June 8, 2022 (the “Closing Date”), Dynamics Special Purpose Acquisition Corp. (“Dynamics” or “DYNS”) consummated a merger pursuant to which Explore Merger Sub, Inc. (“Merger Sub”), a Delaware corporation and wholly owned subsidiary of Dynamics, merged with and into Senti Sub I, Inc., formerly named Senti Biosciences, Inc. (“Legacy Senti”), with Legacy Senti surviving as a wholly-owned subsidiary of Dynamics (such transactions, the “Merger,” and, collectively with the other transactions described in the merger agreement). As a result of the Merger, Dynamics was renamed Senti Biosciences, Inc. On August 7, 2023, the Company completed a transaction with GeneFab, LLC (“GeneFab”), a contract manufacturing and synthetic biology biofoundry focused on next-generation cell and gene therapies. As part of that transaction, the Company disposed of its non-oncology business and in-house manufacturing services and subleased its manufacturing facility to GeneFab. Refer to Note 3. GeneFab Transaction, for further details of the GeneFab transaction, and to Note 14. Related Parties, for related party discussion. Liquidity and Going Concern These consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) assuming the Company will continue as a going concern. The going concern assumption contemplates the realization of assets and satisfaction of liabilities in the normal course of business. The consolidated financial statements do not include any adjustments to the carrying amounts and classification of assets, liabilities, and reported expenses that may be necessary if the Company were unable to continue as a going concern. The Company has devoted substantially all of its efforts to organizing and staffing, business planning, raising capital, and conducting preclinical and clinical studies and has not realized substantial revenues from its planned principal operations. To date, the Company has raised aggregate gross proceeds of $302.5 million from the Merger and a private placement completed concurrently with the Merger (the “PIPE Financing”), the issuance of shares of its common stock, the issuance of shares of redeemable convertible preferred stock, the issuance of convertible notes and, to a lesser extent, through collaboration agreements, government grants and loans. On August 3, 2024, the Company executed an agreement with California Institute of Regenerative Medicine (the “CIRM Grant Agreement”) for a total grant award of $8.0 million. Under the CIRM Grant Agreement, the Company must achieve certain operational milestones to receive the grant tranches. Refer to Note 8. CIRM Grant, for further details of the CIRM Grant Agreement. At September 30, 2024 and December 31, 2023, the Company had an accumulated deficit of $296.5 million and $244.3 million, respectively. The Company’s net losses were $52.2 million and $52.3 million for the nine months ended September 30, 2024 and 2023, respectively. Substantially all of the Company’s operating net losses resulted from costs incurred in connection with the Company’s research and development programs and from general and administrative costs associated with the Company’s operations. The Company expects to incur substantial operating losses and negative cash flows from operations for the foreseeable future as the Company advances its preclinical activities and clinical trials for its product candidates in development. The Company has concluded that substantial doubt exists that the Company’s cash and cash equivalents of $10.5 million as of September 30, 2024 are sufficient for the Company to continue as a going concern for at least one year from the issuance date of these condensed consolidated financial statements. Additional funds will be necessary to maintain current operations and to continue research and development activities. The Company’s continued existence is dependent upon management’s ability to raise capital and ultimately develop profitable operations. While management is devoting substantially all of its efforts to developing the Company’s business and raising capital, there can be no assurance that the Company’s efforts will be successful. Moreover, no assurance can be given that management’s actions will result in profitable operations or the meeting of ongoing liquidity needs. NASDAQ Bid Price Compliance Notice On August 7, 2023, the Company received written notice from the Listing Qualifications Department of the Nasdaq Stock Market LLC (the “Listing Qualifications Department”) notifying the Company that, for the last 30 consecutive trading days, the closing bid price of the Company’s common stock had closed below the minimum bid price requirement of $1.00 per share for continued listing on the Nasdaq Global Market. The Company was provided an initial compliance period of 180 calendar days, or until February 5, 2024, to regain compliance with the minimum bid price requirement. On January 23, 2024, the Company received written notice from the Listing Qualifications Department granting the Company its request to transfer the listing of its common stock from the Nasdaq Global Market tier to the Nasdaq Capital Market tier. The transfer of the listing of the Company’s common stock from the Nasdaq Global Market to the Nasdaq Capital Market took effect with the open of business on January 25, 2024. On February 6, 2024, the Listing Qualifications Department granted the Company’s request for a second 180-calendar day period, or until August 5, 2024, to regain compliance with the $1.00 bid price requirement. On July 17, 2024, the Company filed a Certificate of Amendment to Second Amended and Restated Certificate of Incorporation with the Secretary of State of Delaware, pursuant to which the Company effected a 1-for-10 reverse stock split (the “Reverse Stock Split”) of Company’s issued and outstanding common stock. The Reverse Stock Split became effective as of 5:00 p.m. (Eastern Time) on July 17, 2024, and the Company’s common stock began trading on a split-adjusted basis on the Nasdaq Capital Market at the market open on July 18, 2024. On August 2, 2024, the Company received notification from Nasdaq that for ten consecutive business days, the closing bid price of the Company’s common stock was at least $1.00 per share, and accordingly, the Company regained compliance with the Bid Price Rule, and that the matter was now closed. NASDAQ Audit Committee Requirement Notice On October 22, 2024, the Company received a notice (the “Notice”) from Nasdaq indicating that the Company is no longer compliant with the audit committee requirements as set forth in Nasdaq Listing Rule 5605, the Company has until December 9, 2024 to regain compliance as provided in Nasdaq Listing Rule 5605(c)(4) which defines the cure period. The Company is evaluating the membership of the audit committee and is exploring options to enable it to regain compliance with the Nasdaq Listing Rule 5605 prior to the expiration of the applicable cure period. The Notice has no immediate effect on the listing or trading of the Company’s common stock on the Nasdaq Capital Market.

Commitment and Contingencies (Details) - Corporate Headquarters	Sep. 30, 2024
Lessee, Lease, Description [Line Items]
Operating lease, term of contract (in years)	8 years
Lease renewal term (in years)	8 years

Summary of Significant Accounting Policies (Policies)	9 Months Ended
Summary of Significant Accounting Policies (Policies)	Sep. 30, 2024
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The accompanying condensed consolidated financial statements have been prepared in conformity with U.S. GAAP and the rules and regulations of the Securities and Exchange Commission (“SEC”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). The condensed consolidated financial statements include the accounts of Senti Biosciences, Inc., and its wholly-owned subsidiaries. All intercompany balances and transactions have been eliminated in consolidation. The Company has one business activity and operates in one reportable segment within continuing operations. All long-lived assets of the Company are maintained in the United States. The Company determined that the assets sold to GeneFab in August 2023 met the criteria for presentation as a discontinued operation. As a result, the Company has retrospectively restated its condensed consolidated statements of operations for the three and nine months ended September 30, 2023 to reflect the operating results related to the disposed business in discontinued operations. The Company has chosen not to segregate the cash flows of the disposed business in the condensed consolidated statements of cash flows. Supplemental disclosures related to discontinued operations for the statements of cash flows have been provided in Note 3. GeneFab Transaction. Unless otherwise specified, the disclosures in these condensed consolidated financial statements refer to continuing operations only.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, the valuation of stock-based awards, the accrual for research and development expenses, the valuation of GeneFab Option, the valuation of GeneFab Economic Share, the valuation of the GeneFab Note Receivable, the discount rate used to discount future cash flows for the impairment of long-lived assets, and the determination of the incremental borrowing rate. The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances dictate. Actual results could differ from those estimates.
Concentration of Credit Risk	Concentration of Credit Risk Financial instruments that potentially subject the Company to a significant concentration of credit risk consist of cash, cash equivalents and restricted cash are maintained in checking and money market accounts at multiple financial institutions, which at times, may exceed federally insured limits. As of September 30, 2024 and 2023, the Company has not experienced any credit losses in such accounts or investments. As of September 30, 2024, the Company has prepaid future manufacturing and research services of $3.9 million under an agreement with GeneFab for certain development and manufacturing services agreement which are recorded in GeneFab prepaid expenses - related party in the condensed consolidated balance sheets and $1.1 million receivable related to general and administrative services provided under the transition services agreement which are recorded in GeneFab receivable - related party in the condensed consolidated balance sheets . The prepaid expenses and receivable balances from GeneFab potentially subject the Company to a significant concentration of credit risk if the Company is unable to realize these balances. Refer to Note 3. GeneFab Transaction, for further details of the GeneFab transaction.
Recent Accounting Standards	Recent Accounting Standards In November 2023, the FASB issued ASU No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires an enhanced disclosure of significant segment expenses on an annual and interim basis. This guidance is effective for annual periods beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. Upon adoption, the guidance should be applied retrospectively to all prior periods presented in the financial statements. The Company is currently evaluating the potential impact of adopting this new guidance on its condensed consolidated financial statements and related disclosures. In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures, which improves income tax disclosures by requiring consistent categories and greater disaggregation of information in the effective tax rate reconciliation and income taxes paid disaggregated by jurisdiction. It also includes certain other amendments to improve the effectiveness of income tax disclosures. This guidance is effective for annual periods beginning after December 15, 2024. Early adoption is permitted. Upon adoption, the guidance can be applied prospectively or retrospectively. The Company is currently evaluating the potential impact of adopting this new guidance on its condensed consolidated financial statements and related disclosures. The Company believes that the impact of recently issued accounting standards that are not yet effective will not be material to its financial position or results of operations upon adoption.

Net Loss Per Share

9 Months Ended

Sep. 30, 2024

Earnings Per Share [Abstract]

Net Loss Per Share

A reconciliation of net loss available to common stockholders and the number of shares in the calculation of basic and diluted loss per share is as follows:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Net loss from continuing operations	$	(28,866)	$	(36,615)	$	(52,180)	$	(64,718)
Net income from discontinued operations	—		21,692		—		12,376
Net loss	$	(28,866)	$	(14,923)	$	(52,180)	$	(52,342)

Weighted-average shares used in computing net loss per share, basic and diluted	4,577,122		4,447,223		4,573,307		4,427,458

Net loss per share from continuing operations, basic and diluted	$	(6.31)	$	(8.24)	$	(11.41)	$	(14.62)
Net income per share from discontinued operations, basic and diluted	—		4.88		—		2.80
Net loss per share attributable to common stockholders, basic and diluted	$	(6.31)	$	(3.36)	$	(11.41)	$	(11.82)


	Three Months Ended September 30,		Nine Months Ended September 30,
	2024	2023	2024	2023

Stock options to purchase common stock	921,334	1,191,693	921,334	1,191,693
Unvested early exercised options	1,688	6,752	1,688	6,752
Restricted stock units outstanding	56,423	25,272	56,423	25,272
Performance stock units outstanding	106,806	—	106,806	—
Contingent earnout common stock	100,000	200,000	100,000	200,000
GeneFab Option (Note 3)	1,963,344	1,963,344	1,963,344	1,963,344
Total	3,149,595	3,387,061	3,149,595	3,387,061

Operating Leases (Tables)

9 Months Ended

Sep. 30, 2024

Leases [Abstract]

Schedule of Lease, Cost

A summary of total lease costs and other information for the period relating to the Company’s operating leases is as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Operating lease cost	$	1,312	$	1,323	$	3,943	$	3,952
Short-term lease cost	9		8		26		64
Variable lease cost	268		272		771		894
Total lease cost	$	1,589	$	1,603	$	4,740	$	4,910


	Nine Months Ended September 30,
	2024		2023
Other information:
Operating cash flows net inflows and (outflows) from operating lease	$	(5,412)	$	(2,449)
Right-of-use assets obtained in exchange for operating lease obligations (including remeasurement of right-of-use assets and lease liabilities due to changes in the timing of receipt of lease incentives)	$	—	$	13
Weighted-average remaining lease term (years)	6.9		7.6
Weighted-average discount rate	9.2%		9.2%

Schedule of Lessee, Operating Lease, Liability, Maturity

Maturities of the Company’s lease liabilities as of September 30, 2024, were as follows (in thousands):


2024, for the remainder of the year	$	1,839
2025	7,478
2026	7,712
2027	5,769
2028	4,855
2029	5,000
Thereafter	14,529
Total undiscounted lease payments	47,182
Less imputed interest	(12,576)

Total lease liabilities	$	34,606

Schedule of Operating Lease, Lease Income

A summary of total sublease income for the period relating to the Company’s operating leases is as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
Sublease income - base rent	$	1,314	—		$	3,757	$	—
Sublease income - variable and other	343		—		948		—
Total sublease income	$	1,657	$	—	$	4,705	$	—

Schedule of Lessor, Operating Lease, Payment to be Received, Maturity

Maturities of the Company’s sublease payments for the subleases of both Alameda facility and corporate headquarter premises as of September 30, 2024, were as follows (in thousands):


2024, for the remainder of the year	$	1,205
2025	5,339
2026	5,472
2027	5,053
2028	4,891
2029	5,037
Thereafter	13,258
Total undiscounted sublease payments	$	40,255

Condensed Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Research and development	$ 8,655	$ 9,092	$ 26,584	$ 23,028
Related Party
Research and development	$ 3,790	$ 1,186	$ 11,059	$ 1,186

GeneFab Transaction

9 Months Ended

Sep. 30, 2024

GeneFab Transaction

the condensed consolidated statements of operations and comprehensive loss. Refer to Note 4. Fair Value Measurements.

Refer to Note 14. Related Parties, for GeneFab related party considerations.

Gain on the Disposal of Business

Discontinued Operations

There were no material operating expenses related to the discontinued operations since August 2023, when the transaction with GeneFab closed.

The following table summarizes the condensed operating results of the discontinued operations for the three and nine months ended September 30, 2023 (in thousands):


	Three Months Ended September 30,		Nine months ended September 30,
	2023		2023
Operating expenses:
Research and development	$	1,641	$	9,975
General and administrative	(1,478)		(496)
Total operating expenses	163		9,479
Loss from discontinued operations	(163)		(9,479)
Other expense	(6)		(6)
Gain on disposal of business	21,861		21,861
Net income from discontinued operations	$	21,692	$	12,376

The following table summarizes the condensed cash flow information of the discontinued operations for the nine months ended September 30, 2023 (in thousands):


	Nine months ended September 30,
	2023
Operating activities (noncash adjustments to net income):
Depreciation	$	185
Stock-based compensation	(2,022)

Investing activities:
Purchases of property and equipment	$	(4,079)

Related Parties

Bayer Healthcare LLC

Bayer held 13% of the outstanding shares of the Company’s common stock as of September 30, 2024 and December 31, 2023. Accordingly, Bayer is considered a related party.

Seer, Inc.

GeneFab, LLC.

of research and development expenses under the services agreement during the three and nine months ended September 30, 2024.

- Definition

+ References

+ Details

Stock-Based Compensation

9 Months Ended

Sep. 30, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

Equity Incentive Plans

On June 8, 2022, upon closing of the Merger, the Company adopted a 2022 Stock Incentive Plan (the “2022 Plan”).

As of September 30, 2024, the total number of shares of common stock available for issuance under the 2022 Plan is 510,383.

On August 5, 2022, the Company adopted a 2022 Inducement Equity Plan (the “2022 Inducement Plan”).

As of September 30, 2024, the total number of shares of common stock available for issuance under the 2022 Inducement Plan is 172,312.

On June 8, 2022, upon the Merger, the Company adopted a 2022 Employee Stock Purchase Plan (the “ESPP”).

As of September 30, 2024, the total number of shares of common stock available for issuance under the ESPP is 79,387.

Stock-Based Compensation Expense

Total stock-based compensation expense was as follows (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2024		2023		2024		2023
General and administrative	$	529	$	2,153	$	978	$	8,474
Research and development	139		334		172		1,154
Total stock-based compensation expense from continuing operations	668		2,487		1,150		9,628
Stock-based compensation expense from discontinued operations	—		(2,078)		—		(2,022)
Total stock-based compensation expense	$	668	$	409	$	1,150	$	7,606

As of September 30, 2024, there was $3.5 million of total unrecognized compensation expense related to unvested stock options under all equity plans and restricted stock units, which the Company expects to recognize over the weighted average remaining period of approximately 1.6 years.

Fair Value Measurements

9 Months Ended

Sep. 30, 2024

Fair Value Disclosures [Abstract]

Fair Value Measurements

The following tables summarize the estimated value of cash, cash equivalents and restricted cash (in thousands):


	September 30, 2024
	Adjusted Cost		Estimated Fair Value		Cash and cash equivalents		Restricted cash
Cash	$	1,834	$	1,834	$	1,834	$	—
Level 1:
Money market funds	12,206		12,206		8,645		3,561
Subtotal	12,206		12,206		8,645		3,561






Total	$	14,040	$	14,040	$	10,479	$	3,561


	December 31, 2023
	Adjusted Cost		Estimated Fair Value		Cash and cash equivalents		Restricted cash
Cash	$	4,205	$	4,205	$	4,205	$	—
Level 1:
Money market funds	35,243		35,243		31,721		3,522
Subtotal	35,243		35,243		31,721		3,522






Total	$	39,448	$	39,448	$	35,926	$	3,522

No securities have contractual maturities of longer than one year. There were no transfers between Levels 1, 2, or 3 for any of the periods presented.

GeneFab Note Receivable

The following table presents a summary of the changes in the fair value of the GeneFab Note Receivable (in thousands):


	Note Receivable
Fair value as of December 31, 2023	$	17,240
Change in fair value included in other income (expense)	(17,240)
Fair value as of September 30, 2024	$	—

The fair value of the GeneFab Note Receivable is based on significant unobservable inputs, which represent Level 3 measurements within the fair value hierarchy.

The fair value of the GeneFab Note Receivable as of December 31, 2023 was determined by discounting future payments under multiple probability-weighted scenarios using the Company’s cost of borrowing, which was estimated at 12.53% based on published CCC-rated corporate bond yields. The Company determined that the fair value of the GeneFab Note Receivable was zero as of September 30, 2024, due to the probability that a suitable license agreement, which is a condition of the Company realizing the GeneFab Note Receivable, would not be signed.

GeneFab Option

The following table presents a summary of the changes in the fair value of the GeneFab Option (in thousands):


	GeneFab Option
Fair value as of December 31, 2023	$	(6,331)
Change in fair value included in other income (expense)	6,331
Fair value as of September 30, 2024	$	—

The fair value of the GeneFab Option is based on significant unobservable inputs, which represent Level 3 measurements within the fair value hierarchy.

In determining the fair value of the GeneFab Option, the Company used a Black-Scholes option pricing model. Additionally, the Company determined that the fair value of the GeneFab Option was zero as of September 30, 2024, due to the low probability that a suitable license agreement, which is a condition for exercise of the Option, would be signed.

The significant assumptions utilized in the valuation are described below:


	December 31,
	2023
Current stock price	$	6.60
Expected volatility	98.1		%
Risk-free interest rate	4.12		%
Expected term (years)	2.5

GeneFab Economic Share

The following table presents a summary of the changes in the fair value of the GeneFab Economic Share (in thousands):


	GeneFab Economic Share
Fair value as of December 31, 2023	$	1,816

Change in fair value included in other income (expense)	$	(1,816)
Fair value as of September 30, 2024	$	—

The fair value of the GeneFab Economic Share is based on significant unobservable inputs, which represent Level 3 measurements within the fair value hierarchy.

In determining the fair value of the GeneFab Economic Share, the Company used the option pricing model, which allocates total estimated enterprise value to various classes of equity using the Backsolve method.

The significant assumptions utilized in the valuation as of December 31, 2023 are described below:


	December 31,
	2023
GeneFab equity value	$	35,448
Volatility	65.8		%
Risk free rate	3.93		%
Expected term	4.0

As of September 30, 2024, the Company determined that the fair value of the GeneFab Economic Share was zero due to the low probability of the events triggering the payment underlying the GeneFab Economic Share.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

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+ Details